Protein profile

KP13_05305

Cytochrome c-type biogenesis protein ccmF

Genome: KpKP13

Gene: ccmF AHE44177.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GR06
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Amino acids 650
Annotations 6
Features 84
PDB binders 0
Druggability 1

Overview

Basic information about this protein and its source genome.

Accession
KP13_05305
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ccmF AHE44177.1
Status
annotated
Amino acids
650
Structure source
AlphaFold + ColabFold
GO
GO:0015232 Enables the transfer of heme from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015886 The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
65.123
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.17

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 1
Structure A0A0H3GR06
Pocket Pocket 2
P2Rank 0.998
Structure A0A0H3GR06
Pocket Pocket 1
ColabFold model
FPocket 0.999 · Pocket 27
P2Rank 0.998 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 166 / 4744 genomes with a hit
Normalized 0.035

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0015232 Enables the transfer of heme from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015886 The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

84 records
Show feature table
Start End DB Term Name
492 514 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
637 650 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
206 574 PANTHER PTHR43653 CYTOCHROME C ASSEMBLY PROTEIN-RELATED
206 574 InterPro IPR003567 Cytochrome c-type biogenesis protein
277 299 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
425 444 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
199 209 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
426 444 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
353 375 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
121 143 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
395 414 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
96 114 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
121 142 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
176 198 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
115 120 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
491 510 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
278 306 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
211 233 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
390 412 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
471 490 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
376 394 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
176 198 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
333 352 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
89 296 Pfam PF01578 Cytochrome C assembly protein
89 296 InterPro IPR002541 Cytochrome c assembly protein
415 425 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
132 149 PRINTS PR01410 Cytochrome c-type biogenesis protein signature
132 149 InterPro IPR003567 Cytochrome c-type biogenesis protein
80 106 PRINTS PR01410 Cytochrome c-type biogenesis protein signature
80 106 InterPro IPR003567 Cytochrome c-type biogenesis protein
160 182 PRINTS PR01410 Cytochrome c-type biogenesis protein signature
160 182 InterPro IPR003567 Cytochrome c-type biogenesis protein
295 311 PRINTS PR01410 Cytochrome c-type biogenesis protein signature
295 311 InterPro IPR003567 Cytochrome c-type biogenesis protein
211 237 PRINTS PR01410 Cytochrome c-type biogenesis protein signature
211 237 InterPro IPR003567 Cytochrome c-type biogenesis protein
245 265 PRINTS PR01410 Cytochrome c-type biogenesis protein signature
245 265 InterPro IPR003567 Cytochrome c-type biogenesis protein
311 330 PRINTS PR01410 Cytochrome c-type biogenesis protein signature
311 330 InterPro IPR003567 Cytochrome c-type biogenesis protein
275 295 PRINTS PR01410 Cytochrome c-type biogenesis protein signature
275 295 InterPro IPR003567 Cytochrome c-type biogenesis protein
6 26 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
445 449 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
619 636 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
210 230 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
267 277 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
38 62 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
314 332 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
450 470 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
231 249 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
619 636 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
307 311 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
95 114 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
63 95 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
312 332 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
353 375 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
511 618 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
248 265 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
143 175 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
449 471 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
316 637 Pfam PF16327 Cytochrome c-type biogenesis protein CcmF C-terminal
316 637 InterPro IPR032523 Cytochrome c-type biogenesis protein CcmF, C-terminal
314 329 PRINTS PR01411 Cytochrome c-type biogenesis protein CcmF signature
314 329 InterPro IPR003568 Cytochrome c-type biogenesis protein CcmF
395 414 PRINTS PR01411 Cytochrome c-type biogenesis protein CcmF signature
395 414 InterPro IPR003568 Cytochrome c-type biogenesis protein CcmF
631 644 PRINTS PR01411 Cytochrome c-type biogenesis protein CcmF signature
631 644 InterPro IPR003568 Cytochrome c-type biogenesis protein CcmF
4 28 PRINTS PR01411 Cytochrome c-type biogenesis protein CcmF signature
4 28 InterPro IPR003568 Cytochrome c-type biogenesis protein CcmF
352 369 PRINTS PR01411 Cytochrome c-type biogenesis protein CcmF signature
352 369 InterPro IPR003568 Cytochrome c-type biogenesis protein CcmF
113 136 PRINTS PR01411 Cytochrome c-type biogenesis protein CcmF signature
113 136 InterPro IPR003568 Cytochrome c-type biogenesis protein CcmF
190 205 PRINTS PR01411 Cytochrome c-type biogenesis protein CcmF signature
190 205 InterPro IPR003568 Cytochrome c-type biogenesis protein CcmF
250 266 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
53 641 NCBIfam TIGR00353 heme lyase CcmF/NrfE family subunit
53 641 InterPro IPR003568 Cytochrome c-type biogenesis protein CcmF
27 37 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
40 62 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GR06
AlphaFold — — full sequence — Viewing
ColabFold KP13_05305
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 1.0
7 0.769

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 100.14 0.996
2 33.91 0.948
3 11.41 0.61
4 7.73 0.409
5 5.1 0.234