Protein profile

KP13_05303

putative subunit of heme lyase

Genome: KpKP13

Gene: AHE44179.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUN8
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Amino acids 152
Annotations 3
Features 18
PDB binders 0
Druggability 0.039

Overview

Basic information about this protein and its source genome.

Accession
KP13_05303
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44179.1
Status
annotated
Amino acids
152
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872 Binding to a metal ion. GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
52.903
DEG E-value
2.04e-50
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.67

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.039
Structure A0A0H3GUN8
Pocket Pocket 4
P2Rank
Structure A0A0H3GUN8
Pocket No pockets
ColabFold model
FPocket 0.654 · Pocket 1
P2Rank 0.009 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 90 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0046872 Binding to a metal ion.
  • GO:0017004 The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
1 19 SignalP_EUK SignalP-noTM SignalP-noTM
4 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
5 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
103 122 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
123 152 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
19 102 Gene3D G3DSA:1.10.8.640 Cytochrome C biogenesis protein
19 102 InterPro IPR038297 CcmH/CycL/Ccl2/NrfF domain superfamily
1 19 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
8 146 Pfam PF03918 Cytochrome C biogenesis protein
8 146 InterPro IPR005616 CcmH/CycL/Ccl2/NrfF family
20 102 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
31 97 CDD cd16378 CcmH_N
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
5 130 PANTHER PTHR47870 CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCMH
15 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
19 99 FunFam G3DSA:1.10.8.640:FF:000001 Cytochrome c-type biogenesis protein
100 122 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUN8
AlphaFold — — full sequence — Viewing
ColabFold KP13_05303
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer