Protein profile

KP13_31930

transposase insD for insertion element IS2I

Genome: KpKP13

Gene: AHE44191.1 Structure source: AlphaFold + ColabFold UniProt A0A377YTG5
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Amino acids 293
Annotations 2
Features 12
PDB binders 0
Druggability 0.178

Overview

Basic information about this protein and its source genome.

Accession
KP13_31930
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44191.1
Status
annotated
Amino acids
293
Structure source
AlphaFold + ColabFold
GO
GO:0003676 Binding to a nucleic acid. GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
89.79

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.178
Structure A0A377YTG5
Pocket Pocket 13
P2Rank 0.352
Structure A0A377YTG5
Pocket Pocket 1
ColabFold model
FPocket 0.198 · Pocket 5
P2Rank 0.287 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 12 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003676 Binding to a nucleic acid.
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
120 290 Gene3D G3DSA:3.30.420.10 -
120 290 InterPro IPR036397 Ribonuclease H superfamily
127 228 Pfam PF00665 Integrase core domain
127 228 InterPro IPR001584 Integrase, catalytic core
126 291 SUPERFAMILY SSF53098 Ribonuclease H-like
126 291 InterPro IPR012337 Ribonuclease H-like superfamily
109 290 ProSiteProfiles PS50994 Integrase catalytic domain profile.
109 290 InterPro IPR001584 Integrase, catalytic core
50 105 Pfam PF13276 HTH-like domain
50 105 InterPro IPR025948 HTH-like domain
14 286 NCBIfam NF033516 IS3 family transposase
26 288 PANTHER PTHR46889 TRANSPOSASE INSF FOR INSERTION SEQUENCE IS3B-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A377YTG5
AlphaFold — — full sequence — Viewing
ColabFold KP13_31930
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.37 0.183
2 1.75 0.032
3 1.72 0.03
4 1.33 0.015