Protein profile

KP13_05088

Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B

Genome: KpKP13

Gene: AHE44206.1 lpsJ Structure source: AlphaFold + ColabFold UniProt A0A0H3GPA6
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Amino acids 218
Annotations 1
Features 15
PDB binders 0
Druggability 0.415

Overview

Basic information about this protein and its source genome.

Accession
KP13_05088
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44206.1 lpsJ
Status
annotated
Amino acids
218
Structure source
AlphaFold + ColabFold
GO
GO:0008410 Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
49.767
Human E-value
2.59e-69
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
51.835
DEG E-value
1.21e-77
Localization
Cytoplasmic
ColabFold pLDDT
96.27

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.415
Structure A0A0H3GPA6
Pocket Pocket 7
P2Rank 0.699
Structure A0A0H3GPA6
Pocket Pocket 1
ColabFold model
FPocket 0.222 · Pocket 6
P2Rank 0.657 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 252 / 4744 genomes with a hit
Normalized 0.053

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0008410 Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
3 216 PANTHER PTHR13707 KETOACID-COENZYME A TRANSFERASE
3 216 InterPro IPR004165 Coenzyme A transferase family I
1 213 FunFam G3DSA:3.40.1080.10:FF:000001 Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b
3 216 SUPERFAMILY SSF100950 NagB/RpiA/CoA transferase-like
3 216 InterPro IPR037171 NagB/RpiA transferase-like
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 200 Pfam PF01144 Coenzyme A transferase
5 200 InterPro IPR004165 Coenzyme A transferase family I
43 51 ProSitePatterns PS01274 Coenzyme A transferases signature 2.
43 51 InterPro IPR004164 Coenzyme A transferase active site
1 213 Gene3D G3DSA:3.40.1080.10 -
5 201 SMART SM00882 CoA_trans_3
5 201 InterPro IPR004165 Coenzyme A transferase family I
3 207 NCBIfam TIGR02428 3-oxoacid CoA-transferase subunit B
3 207 InterPro IPR012791 3-oxoacid CoA-transferase, subunit B

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPA6
AlphaFold — — full sequence — Viewing
ColabFold KP13_05088
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.415
10 0.22

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.88 0.475
2 1.83 0.035