Protein profile

KP13_05101

putative hydrolase

Genome: KpKP13

Gene: AHE44219.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTX0
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Amino acids 427
Annotations 4
Features 6
PDB binders 6
Druggability 0.891

Overview

Basic information about this protein and its source genome.

Accession
KP13_05101
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44219.1
Status
annotated
Amino acids
427
Structure source
AlphaFold + ColabFold
GO
GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0004131 Catalysis of the reaction: cytosine + H2O = uracil + NH4+. GO:0035888 Catalysis of the reaction: H+ + H2O + isoguanine = NH4+ + xanthine. GO:0006209 The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.21

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.891
Structure A0A0H3GTX0
Pocket Pocket 2
P2Rank 0.743
Structure A0A0H3GTX0
Pocket Pocket 1
ColabFold model
FPocket 0.8 · Pocket 1
P2Rank 0.759 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 5 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
  • GO:0004131 Catalysis of the reaction: cytosine + H2O = uracil + NH4+.
  • GO:0035888 Catalysis of the reaction: H+ + H2O + isoguanine = NH4+ + xanthine.
  • GO:0006209 The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
35 412 Gene3D G3DSA:2.30.40.10 Urease, subunit C, domain 1
35 412 InterPro IPR011059 Metal-dependent hydrolase, composite domain superfamily
72 375 Gene3D G3DSA:3.20.20.140 -
38 420 PANTHER PTHR32027 CYTOSINE DEAMINASE
71 362 SUPERFAMILY SSF51556 Metallo-dependent hydrolases
71 362 InterPro IPR032466 Metal-dependent hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTX0
AlphaFold — — full sequence — Viewing
ColabFold KP13_05101
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.891

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.24 0.75
2 3.87 0.151
3 1.27 0.013
4 1.12 0.008

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

10 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
FPY
1RA5
P25524 132.1 Da LogP -0.57 TPSA 61.4 ✓ Ro5 ✓ Clean C1=C([C@@H](NC(=O)N1)O)F
HPY
1K70
P25524 114.1 Da LogP -0.87 TPSA 61.4 ✓ Ro5 ✓ Clean C1=CNC(=O)N[C@H]1O
IGA
3RN6
P25524 151.1 Da LogP -0.77 TPSA 100.5 ✓ Ro5 ✓ Clean c1[nH]c2c(n1)NC(=O)N=C2N
MLI
4CQB
O52063 102.0 Da LogP -3.12 TPSA 80.3 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(=O)[O-]
O7U
3O7U
P25524 147.1 Da LogP -0.08 TPSA 84.2 ✓ Ro5 ✓ Clean C1=C[P@](=O)(NC(=O)N1)N
PXN
3O7U
P25524 368.5 Da LogP -0.44 TPSA 117.8 ✓ Ro5 ✓ Clean C[C@H](COCC(COC[C@@H](C)O)(COC[C@@H](C)O)COC[C@…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.