Protein profile

KP13_05104

ABC transport system periplasmic binding component-related protein

Genome: KpKP13

Gene: AHE44222.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZ34
Export view
Amino acids 329
Annotations 1
Features 13
PDB binders 0
Druggability 0.626

Overview

Basic information about this protein and its source genome.

Accession
KP13_05104
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44222.1
Status
annotated
Amino acids
329
Structure source
AlphaFold + ColabFold
GO
GO:0009228 The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.37

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.626
Structure A0A0H3GZ34
Pocket Pocket 1
P2Rank 0.917
Structure A0A0H3GZ34
Pocket Pocket 1
ColabFold model
FPocket 0.013 · Pocket 3
P2Rank 0.958 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 11 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0009228 The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 28 SignalP_EUK SignalP-noTM SignalP-noTM
13 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
25 28 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
29 329 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
44 245 Pfam PF09084 NMT1/THI5 like
44 245 InterPro IPR015168 SsuA/THI5-like
27 323 PANTHER PTHR31528 4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED
27 323 InterPro IPR027939 NMT1/THI5 family
1 12 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
35 301 Gene3D G3DSA:3.40.190.10 -
1 28 Phobius SIGNAL_PEPTIDE Signal peptide region
37 244 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
113 208 Gene3D G3DSA:3.40.190.10 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZ34
AlphaFold — — full sequence — Viewing
ColabFold KP13_05104
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.005
7 0.003
16 0.003
10 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 32.57 0.917
2 6.29 0.263