Protein profile

KP13_05115

Oligopeptide ABC transport system permease component

Genome: KpKP13

Gene: AHE44233.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZ19
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Amino acids 319
Annotations 3
Features 34
PDB binders 0
Druggability 0.391

Overview

Basic information about this protein and its source genome.

Accession
KP13_05115
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44233.1
Status
annotated
Amino acids
319
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.92

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.391
Structure A0A0H3GZ19
Pocket Pocket 1
P2Rank 0.69
Structure A0A0H3GZ19
Pocket Pocket 1
ColabFold model
FPocket 0.449 · Pocket 11
P2Rank 0.719 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 38 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records
Show feature table
Start End DB Term Name
261 285 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
178 200 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
88 299 SUPERFAMILY SSF161098 MetI-like
88 299 InterPro IPR035906 MetI-like superfamily
155 173 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
9 28 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
93 306 CDD cd06261 TM_PBP2
93 306 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
129 154 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
286 311 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
174 195 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
133 155 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
196 238 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 317 PANTHER PTHR43163 DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPB-RELATED
92 117 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
98 120 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
47 91 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
111 316 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
111 316 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
83 309 Gene3D G3DSA:1.10.3720.10 -
83 309 InterPro IPR035906 MetI-like superfamily
29 46 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
238 260 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 73 Pfam PF19300 Binding-prot-dependent transport system membrane comp, N-term
1 73 InterPro IPR045621 ABC transporter type 1, GsiC-like, N-terminal domain
1 15 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
16 28 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
289 311 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 46 Phobius SIGNAL_PEPTIDE Signal peptide region
93 304 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
93 304 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
118 128 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
312 319 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
239 260 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZ19
AlphaFold — — full sequence — Viewing
ColabFold KP13_05115
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.391

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.77 0.624
2 3.77 0.145
3 2.42 0.065
4 2.05 0.045