Protein profile

KP13_05120

DeoR family transcriptional regulator

Genome: KpKP13

Gene: AHE44238.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GP87
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Amino acids 256
Annotations 2
Features 21
PDB binders 0
Druggability 0.904

Overview

Basic information about this protein and its source genome.

Accession
KP13_05120
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44238.1
Status
annotated
Amino acids
256
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.13

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.904
Structure A0A0H3GP87
Pocket Pocket 1
P2Rank 0.874
Structure A0A0H3GP87
Pocket Pocket 1
ColabFold model
FPocket 0.889 · Pocket 2
P2Rank 0.868 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 33 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
43 61 PRINTS PR00037 LacR bacterial regulatory protein HTH signature
43 61 InterPro IPR001034 DeoR-type HTH domain
29 43 PRINTS PR00037 LacR bacterial regulatory protein HTH signature
29 43 InterPro IPR001034 DeoR-type HTH domain
8 243 PANTHER PTHR30363 HTH-TYPE TRANSCRIPTIONAL REGULATOR SRLR-RELATED
3 59 Gene3D G3DSA:1.10.10.10 -
3 59 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
11 63 SMART SM00420 deor2
11 63 InterPro IPR001034 DeoR-type HTH domain
78 235 SUPERFAMILY SSF100950 NagB/RpiA/CoA transferase-like
78 235 InterPro IPR037171 NagB/RpiA transferase-like
11 45 ProSitePatterns PS00894 DeoR-type HTH domain signature.
11 45 InterPro IPR018356 Transcription regulator, HTH DeoR-type, conserved site
8 63 ProSiteProfiles PS51000 DeoR-type HTH domain profile.
8 63 InterPro IPR001034 DeoR-type HTH domain
76 237 SMART SM01134 DeoRC_2
10 63 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
10 63 InterPro IPR036390 Winged helix DNA-binding domain superfamily
78 235 Pfam PF00455 DeoR C terminal sensor domain
78 235 InterPro IPR014036 DeoR C-terminal sensor domain
11 63 Pfam PF08220 DeoR-like helix-turn-helix domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GP87
AlphaFold — — full sequence — Viewing
ColabFold KP13_05120
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.904

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 14.81 0.735