Protein profile

KP13_05133

decarboxylase family protein

Genome: KpKP13

Gene: AHE44252.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTR6
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Amino acids 192
Annotations 5
Features 8
PDB binders 2
Druggability 0.365

Overview

Basic information about this protein and its source genome.

Accession
KP13_05133
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44252.1
Status
annotated
Amino acids
192
Structure source
AlphaFold + ColabFold
EC
3.2.2.n1
GO
GO:0009691 The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008714 Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
41.618
DEG E-value
1.21e-44
Localization
Cytoplasmic
ColabFold pLDDT
94.62

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.365
Structure A0A0H3GTR6
Pocket Pocket 5
P2Rank 0.563
Structure A0A0H3GTR6
Pocket Pocket 1
ColabFold model
FPocket 0.443 · Pocket 7
P2Rank 0.513 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 95 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0009691 The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0008714 Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
46 173 Pfam PF03641 Possible lysine decarboxylase
46 173 InterPro IPR031100 LOG family
1 191 Gene3D G3DSA:3.40.50.450 -
2 183 PANTHER PTHR31223 LOG FAMILY PROTEIN YJL055W
1 189 FunFam G3DSA:3.40.50.450:FF:000012 LOG family protein YvdD
1 174 SUPERFAMILY SSF102405 MCP/YpsA-like
2 179 NCBIfam TIGR00730 Rossman fold protein, TIGR00730 family
2 179 InterPro IPR005269 Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTR6
AlphaFold — — full sequence — Viewing
ColabFold KP13_05133
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.365
3 0.229

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.78 0.412
2 0.93 0.004

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

17 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
FLC
5ZI9
Q9FBL8 189.1 Da LogP -5.25 TPSA 140.6 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
TAR
5AJT
M1VUY5 150.1 Da LogP -2.12 TPSA 115.1 ✓ Ro5 ✓ Clean [C@H]([C@@H](C(=O)O)O)(C(=O)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.