Protein profile

KP13_05155

putative transporter

Genome: KpKP13

Gene: AHE44274.1 Structure source: AlphaFold + ColabFold UniProt A0A086IKU3
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Amino acids 674
Annotations 3
Features 40
PDB binders 0
Druggability 0.948

Overview

Basic information about this protein and its source genome.

Accession
KP13_05155
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44274.1
Status
annotated
Amino acids
674
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
76.006
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.04

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.948
Structure A0A086IKU3
Pocket Pocket 3
P2Rank 0.966
Structure A0A086IKU3
Pocket Pocket 1
ColabFold model
FPocket 0.714 · Pocket 24
P2Rank 0.96 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 94 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

40 records
Show feature table
Start End DB Term Name
410 432 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
23 41 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
383 405 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
145 170 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
516 674 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
498 515 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
118 137 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
94 113 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
464 483 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
157 179 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
46 65 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
412 434 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 663 Pfam PF04632 Fusaric acid resistance protein family
20 663 InterPro IPR006726 Para-hydroxybenzoic acid efflux pump subunit AaeB/fusaric acid resistance protein
498 515 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
72 88 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
462 478 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
42 46 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
66 71 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
94 114 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
438 457 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
456 461 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
362 379 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
47 65 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
17 566 PANTHER PTHR30509 P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT-RELATED
438 455 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
140 144 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
171 359 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
21 41 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
360 379 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
72 90 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
380 384 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
121 139 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
89 93 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
115 120 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
404 409 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
479 497 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
433 437 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
385 403 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A086IKU3
AlphaFold — — full sequence — Viewing
ColabFold KP13_05155
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.948
7 0.863
16 0.68
38 0.405

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 36.56 0.956
2 7.11 0.369
3 5.82 0.284
4 5.05 0.23
5 4.01 0.16