Protein profile

KP13_05156

HlyD-family protein

Genome: KpKP13

Gene: AHE44275.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUH7
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Amino acids 298
Annotations 3
Features 17
PDB binders 0
Druggability 0.075

Overview

Basic information about this protein and its source genome.

Accession
KP13_05156
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44275.1
Status
annotated
Amino acids
298
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.04

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.075
Structure A0A0H3GUH7
Pocket Pocket 10
P2Rank 0.03
Structure A0A0H3GUH7
Pocket Pocket 1
ColabFold model
FPocket 0.069 · Pocket 5
P2Rank 0.028 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 92 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
24 28 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
41 90 Pfam PF13533 Biotin-lipoyl like
41 90 InterPro IPR039562 Membrane fusion protein, biotin-lipoyl like domain
1 10 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 28 Phobius SIGNAL_PEPTIDE Signal peptide region
42 119 Gene3D G3DSA:2.40.50.100 -
10 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
40 253 NCBIfam TIGR01730 efflux RND transporter periplasmic adaptor subunit
40 253 InterPro IPR006143 RND efflux pump, membrane fusion protein
80 111 Coils Coil Coil
7 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
179 297 Gene3D G3DSA:2.40.30.170 -
3 295 PANTHER PTHR30367 P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT AAEA-RELATED
29 298 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
165 244 Pfam PF13437 HlyD family secretion protein
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
40 253 SUPERFAMILY SSF111369 HlyD-like secretion proteins

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUH7
AlphaFold — — full sequence — Viewing
ColabFold KP13_05156
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.73 0.031