Protein profile

KP13_05162

Membrane-bound lysozyme inhibitor of C-type lysozyme

Genome: KpKP13

Gene: mliC AHE44281.1 Structure source: AlphaFold + ColabFold UniProt W1DJH0
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Amino acids 116
Annotations 0
Features 11
PDB binders 0
Druggability 0.622

Overview

Basic information about this protein and its source genome.

Accession
KP13_05162
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
mliC AHE44281.1
Status
annotated
Amino acids
116
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
82.29

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.622
Structure W1DJH0
Pocket Pocket 9
P2Rank 0.105
Structure W1DJH0
Pocket Pocket 1
ColabFold model
FPocket 0.531 · Pocket 9
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 64 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
12 29 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
13 32 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
35 112 SUPERFAMILY SSF141488 YdhA-like
35 112 InterPro IPR036328 C-type lysozyme inhibitor superfamily
35 116 Gene3D G3DSA:2.40.128.200 -
35 116 InterPro IPR036328 C-type lysozyme inhibitor superfamily
42 103 Pfam PF09864 Membrane-bound lysozyme-inhibitor of c-type lysozyme
42 103 InterPro IPR018660 C-type lysozyme inhibitor
30 116 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 25 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_W1DJH0
AlphaFold — — full sequence — Viewing
ColabFold KP13_05162
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.622
4 0.606

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.51 0.07
2 0.77 0.002