Protein profile

KP13_05171

Electron transport complex protein rnfE

Genome: KpKP13

Gene: AHE44290.1 rnfE Structure source: AlphaFold + ColabFold UniProt A0A0H3GUG7
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Amino acids 232
Annotations 5
Features 25
PDB binders 0
Druggability 0.955

Overview

Basic information about this protein and its source genome.

Accession
KP13_05171
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44290.1 rnfE
Status
annotated
Amino acids
232
Structure source
AlphaFold + ColabFold
EC
7.-.-.-
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0012505 A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
87.446
DEG E-value
1.49e-135
Localization
CytoplasmicMembrane
ColabFold pLDDT
76.95

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.955
Structure A0A0H3GUG7
Pocket Pocket 5
P2Rank 0.092
Structure A0A0H3GUG7
Pocket Pocket 1
ColabFold model
FPocket 0.55 · Pocket 2
P2Rank 0.106 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 159 / 4744 genomes with a hit
Normalized 0.034

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.
  • GO:0012505 A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
93 113 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
126 148 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
3 214 PANTHER PTHR30586 ELECTRON TRANSPORT COMPLEX PROTEIN RNFE
183 206 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
88 92 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
38 57 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
125 148 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
34 56 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
69 87 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 210 Hamap MF_00478 Ion-translocating oxidoreductase complex subunit E [rsxE].
1 210 InterPro IPR010968 Ion-translocating oxidoreductase complex subunit E
6 199 Pfam PF02508 Rnf-Nqr subunit, membrane protein
6 199 InterPro IPR003667 NqrDE/RnfAE
69 87 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 219 PIRSF PIRSF006102 NQR_DE
1 219 InterPro IPR003667 NqrDE/RnfAE
1 37 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
184 206 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
149 182 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
58 68 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
91 113 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
114 124 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
7 208 NCBIfam TIGR01948 RnfABCDGE type electron transport complex subunit E
7 208 InterPro IPR010968 Ion-translocating oxidoreductase complex subunit E
207 232 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUG7
AlphaFold — — full sequence — Viewing
ColabFold KP13_05171
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.955
2 0.713

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.84 0.089
2 1.64 0.027