Protein profile

KP13_05172

Electron transport complex protein rnfG

Genome: KpKP13

Gene: rnfG AHE44291.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GP60
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Amino acids 207
Annotations 6
Features 19
PDB binders 0
Druggability 0.296

Overview

Basic information about this protein and its source genome.

Accession
KP13_05172
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
rnfG AHE44291.1
Status
annotated
Amino acids
207
Structure source
AlphaFold + ColabFold
EC
7.-.-.-
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
80.583
DEG E-value
2.61e-127
Localization
Periplasmic
ColabFold pLDDT
92.96

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.296
Structure A0A0H3GP60
Pocket Pocket 3
P2Rank 0.02
Structure A0A0H3GP60
Pocket Pocket 1
ColabFold model
FPocket 0.332 · Pocket 3
P2Rank 0.017 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 131 / 4744 genomes with a hit
Normalized 0.028

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
  • GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.
  • GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
19 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
2 205 PANTHER PTHR36118 ION-TRANSLOCATING OXIDOREDUCTASE COMPLEX SUBUNIT G
2 205 InterPro IPR010209 Ion-translocating oxidoreductase complex, subunit RnfG/RsxG
1 25 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
10 193 NCBIfam TIGR01947 RnfABCDGE type electron transport complex subunit G
10 193 InterPro IPR010209 Ion-translocating oxidoreductase complex, subunit RnfG/RsxG
1 25 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 203 PIRSF PIRSF006091 E_trnsport_RnfG
1 203 InterPro IPR010209 Ion-translocating oxidoreductase complex, subunit RnfG/RsxG
10 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
26 207 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
100 188 Pfam PF04205 FMN-binding domain
100 188 InterPro IPR007329 FMN-binding
100 192 SMART SM00900 FMN_bind_2
100 192 InterPro IPR007329 FMN-binding
3 194 Hamap MF_00479 Ion-translocating oxidoreductase complex subunit G [rsxG].
3 194 InterPro IPR010209 Ion-translocating oxidoreductase complex, subunit RnfG/RsxG
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GP60
AlphaFold — — full sequence — Viewing
ColabFold KP13_05172
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.296