Protein profile

KP13_31939

Electron transport complex protein rnfC

Genome: KpKP13

Gene: rnfC AHE44293.1 Structure source: AlphaFold + ColabFold UniProt A0A871B2A6
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Amino acids 719
Annotations 7
Features 33
PDB binders 0
Druggability 0.643

Overview

Basic information about this protein and its source genome.

Accession
KP13_31939
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
rnfC AHE44293.1
Status
annotated
Amino acids
719
Structure source
AlphaFold + ColabFold
EC
7.-.-.-
GO
GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872 Binding to a metal ion. GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
81.294
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
80.98

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.643
Structure A0A871B2A6
Pocket Pocket 51
P2Rank 0.951
Structure A0A871B2A6
Pocket Pocket 1
ColabFold model
FPocket 0.438 · Pocket 1
P2Rank 0.893 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 106 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0046872 Binding to a metal ion.
  • GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.

Sequence Features

Domain/signature hits from InterPro and related databases.

33 records
Show feature table
Start End DB Term Name
559 579 Coils Coil Coil
627 647 Coils Coil Coil
371 446 Gene3D G3DSA:3.30.70.20 -
377 430 Pfam PF12838 4Fe-4S dicluster domain
377 430 InterPro IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
523 543 Coils Coil Coil
14 115 Pfam PF13375 RnfC Barrel sandwich hybrid domain
14 115 InterPro IPR026902 RnfC Barrel sandwich hybrid domain
407 436 ProSiteProfiles PS51379 4Fe-4S ferredoxin-type iron-sulfur binding domain profile.
407 436 InterPro IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
1 578 PANTHER PTHR43034 ION-TRANSLOCATING OXIDOREDUCTASE COMPLEX SUBUNIT C
1 578 InterPro IPR010208 Ion-translocating oxidoreductase complex, subunit RnfC/RsxC
139 283 Pfam PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit
139 283 InterPro IPR011538 NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain
416 427 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature.
416 427 InterPro IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
661 681 Coils Coil Coil
674 697 MobiDBLite mobidb-lite consensus disorder prediction
13 445 NCBIfam TIGR01945 RnfABCDGE type electron transport complex subunit C
13 445 InterPro IPR010208 Ion-translocating oxidoreductase complex, subunit RnfC/RsxC
367 397 ProSiteProfiles PS51379 4Fe-4S ferredoxin-type iron-sulfur binding domain profile.
367 397 InterPro IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
593 613 Coils Coil Coil
336 444 SUPERFAMILY SSF46548 alpha-helical ferredoxin
443 470 Coils Coil Coil
1 719 Hamap MF_00461 Ion-translocating oxidoreductase complex subunit C [rsxC].
1 719 InterPro IPR010208 Ion-translocating oxidoreductase complex, subunit RnfC/RsxC
296 344 Pfam PF10531 SLBB domain
296 344 InterPro IPR019554 Soluble ligand binding domain
94 303 SUPERFAMILY SSF142019 Nqo1 FMN-binding domain-like
94 303 InterPro IPR037225 NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily
144 291 Gene3D G3DSA:3.40.50.11540 -
144 291 InterPro IPR037225 NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A871B2A6
AlphaFold — — full sequence — Viewing
ColabFold KP13_31939
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
51 0.643
1 0.262

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.89 0.884
2 2.88 0.092
3 2.02 0.044
4 1.83 0.035
5 1.46 0.02