Protein profile

KP13_04421

Electron transport complex protein rnfB

Genome: KpKP13

Gene: rnfB AHE44294.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUG2
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Amino acids 185
Annotations 7
Features 28
PDB binders 2
Druggability 0.369

Overview

Basic information about this protein and its source genome.

Accession
KP13_04421
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
rnfB AHE44294.1
Status
annotated
Amino acids
185
Structure source
AlphaFold + ColabFold
EC
7.-.-.-
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
60.355
DEG E-value
1.6800000000000001e-72
Localization
Cytoplasmic
ColabFold pLDDT
87.03

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.369
Structure A0A0H3GUG2
Pocket Pocket 4
P2Rank 0.225
Structure A0A0H3GUG2
Pocket Pocket 1
ColabFold model
FPocket 0.359 · Pocket 2
P2Rank 0.171 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 184 / 4744 genomes with a hit
Normalized 0.039

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
  • GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.
  • GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
25 177 PANTHER PTHR42859 OXIDOREDUCTASE
103 157 Pfam PF14697 4Fe-4S dicluster domain
140 151 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature.
140 151 InterPro IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
1 184 PIRSF PIRSF005784 RnfB
1 184 InterPro IPR016463 Electron transport complex, RnfB/RsxB, Proteobacteria
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
31 169 SUPERFAMILY SSF54862 4Fe-4S ferredoxins
24 185 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
30 77 Gene3D G3DSA:1.10.15.40 -
101 130 ProSiteProfiles PS51379 4Fe-4S ferredoxin-type iron-sulfur binding domain profile.
101 130 InterPro IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
1 162 Hamap MF_00463 Ion-translocating oxidoreductase complex subunit B [rsxB].
1 162 InterPro IPR010207 Ion-translocating oxidoreductase complex, RnfB/RsxB
25 84 ProSiteProfiles PS51656 4Fe-4S domain profile.
25 84 InterPro IPR007202 4Fe-4S domain
37 69 Pfam PF04060 Putative Fe-S cluster
37 69 InterPro IPR007202 4Fe-4S domain
1 16 SignalP_EUK SignalP-noTM SignalP-noTM
30 81 FunFam G3DSA:1.10.15.40:FF:000001 Ion-translocating oxidoreductase complex subunit B
2 183 NCBIfam TIGR01944 RnfABCDGE type electron transport complex subunit B
2 183 InterPro IPR010207 Ion-translocating oxidoreductase complex, RnfB/RsxB
16 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
78 174 Gene3D G3DSA:3.30.70.20 -
131 160 ProSiteProfiles PS51379 4Fe-4S ferredoxin-type iron-sulfur binding domain profile.
131 160 InterPro IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUG2
AlphaFold — — full sequence — Viewing
ColabFold KP13_04421
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.369

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.29 0.177
2 1.54 0.023
3 1.14 0.009

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

22 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
CMO
1E08
P07598 28.0 Da LogP -0.04 TPSA 19.9 ✓ Ro5 ✓ Clean [C-]#[O+]
PDT
1E08
P07598 108.2 Da LogP 1.24 TPSA 0.0 ✓ Ro5 ✓ Clean C(CS)CS

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.