Protein profile

KP13_04438

PQQ-dependent dehydrogenase, glucose/quinate/shikimate family

Genome: KpKP13

Gene: AHE44311.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTK8
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Amino acids 790
Annotations 6
Features 46
PDB binders 0
Druggability 0.832

Overview

Basic information about this protein and its source genome.

Accession
KP13_04438
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44311.1
Status
annotated
Amino acids
790
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016614 Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0048038 Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008876 Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
40.87
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
94.21

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.832
Structure A0A0H3GTK8
Pocket Pocket 17
P2Rank 0.932
Structure A0A0H3GTK8
Pocket Pocket 1
ColabFold model
FPocket 0.915 · Pocket 1
P2Rank 0.95 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 58 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0016614 Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0048038 Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0008876 Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol.

Sequence Features

Domain/signature hits from InterPro and related databases.

46 records
Show feature table
Start End DB Term Name
148 786 Gene3D G3DSA:2.140.10.10 -
43 60 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
664 751 Pfam PF13360 PQQ-like domain
664 751 InterPro IPR002372 Pyrrolo-quinoline quinone repeat
61 66 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
168 786 CDD cd10280 PQQ_mGDH
168 786 InterPro IPR017511 PQQ-dependent membrane bound dehydrogenase
121 140 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
634 681 SMART SM00564 ire1_9
634 681 InterPro IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
338 379 SMART SM00564 ire1_9
338 379 InterPro IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
710 742 SMART SM00564 ire1_9
710 742 InterPro IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
481 512 SMART SM00564 ire1_9
481 512 InterPro IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
219 250 SMART SM00564 ire1_9
219 250 InterPro IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
281 313 SMART SM00564 ire1_9
281 313 InterPro IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
408 457 SMART SM00564 ire1_9
408 457 InterPro IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
36 58 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
403 424 ProSitePatterns PS00364 Bacterial quinoprotein dehydrogenases signature 2.
403 424 InterPro IPR001479 Quinoprotein dehydrogenase, conserved site
16 37 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
92 114 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
13 32 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
65 82 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
17 787 NCBIfam TIGR03074 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family
17 787 InterPro IPR017511 PQQ-dependent membrane bound dehydrogenase
143 790 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 15 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
145 770 PANTHER PTHR32303 QUINOPROTEIN ALCOHOL DEHYDROGENASE (CYTOCHROME C)
121 142 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
96 114 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
115 120 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
38 42 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
164 772 SUPERFAMILY SSF50998 Quinoprotein alcohol dehydrogenase-like
164 772 InterPro IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
224 254 Pfam PF01011 PQQ enzyme repeat
224 254 InterPro IPR002372 Pyrrolo-quinoline quinone repeat
440 467 Pfam PF01011 PQQ enzyme repeat
440 467 InterPro IPR002372 Pyrrolo-quinoline quinone repeat
91 95 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
67 90 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTK8
AlphaFold — — full sequence — Viewing
ColabFold KP13_04438
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
17 0.832

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 24.99 0.903
2 21.27 0.868
3 9.59 0.516
4 9.54 0.513
5 4.25 0.175