Protein profile

KP13_04448

putative LpxA-like enzyme

Genome: KpKP13

Gene: AHE44321.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQK9
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Amino acids 326
Annotations 2
Features 13
PDB binders 0
Druggability 0.357

Overview

Basic information about this protein and its source genome.

Accession
KP13_04448
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44321.1
Status
annotated
Amino acids
326
Structure source
AlphaFold + ColabFold
GO
GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.09

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.357
Structure A0A0H3GQK9
Pocket Pocket 8
P2Rank 0.177
Structure A0A0H3GQK9
Pocket Pocket 1
ColabFold model
FPocket 0.508 · Pocket 7
P2Rank 0.167 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 58 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
  • GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
180 258 CDD cd00208 LbetaH
223 313 Gene3D G3DSA:2.160.10.10 Hexapeptide repeat proteins
169 185 Pfam PF18836 YdcK Beta solenoid repeat
169 185 InterPro IPR040831 YdcK Beta solenoid repeat
153 168 Pfam PF18836 YdcK Beta solenoid repeat
153 168 InterPro IPR040831 YdcK Beta solenoid repeat
107 122 Pfam PF18836 YdcK Beta solenoid repeat
107 122 InterPro IPR040831 YdcK Beta solenoid repeat
1 326 NCBIfam NF040481 YdcK family protein
5 291 SUPERFAMILY SSF51161 Trimeric LpxA-like enzymes
5 291 InterPro IPR011004 Trimeric LpxA-like superfamily
44 222 Gene3D G3DSA:2.160.10.10 Hexapeptide repeat proteins
153 322 PANTHER PTHR43584 NUCLEOTIDYL TRANSFERASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQK9
AlphaFold — — full sequence — Viewing
ColabFold KP13_04448
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.357

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.02 0.099