Protein profile

KP13_04449

Tellurite resistance protein tehA

Genome: KpKP13

Gene: AHE44322.1 tehA Structure source: AlphaFold + ColabFold UniProt A0A0H3GTJ7

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Amino acids 334

Annotations 7

Features 39

PDB binders 3

Druggability 0.983

Overview

Basic information about this protein and its source genome.

Accession: KP13_04449
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE44322.1 tehA
Status: annotated
Amino acids: 334
Structure source: AlphaFold + ColabFold

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042802 Binding to an identical protein or proteins. GO:0046583 Enables the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane. GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 0.0
Localization: CytoplasmicMembrane
ColabFold pLDDT: 94.72

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.983

Structure A0A0H3GTJ7

Pocket Pocket 16

P2Rank 0.821

Structure A0A0H3GTJ7

Pocket Pocket 1

ColabFold model

FPocket 0.953 · Pocket 1

P2Rank 0.852 · Pocket 1

Core conservation Accessory gene

Roary core

CoreCruncher accessory

Gut microbiome 59 / 4744 genomes with a hit

Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0042802 Binding to an identical protein or proteins.
GO:0046583 Enables the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane.
GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
GO:0046690 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus.

Sequence Features

Domain/signature hits from InterPro and related databases.

39 records

Show feature table

Start	End	DB	Term	Name
127	153	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
13	35	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
43	64	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
8	324	PANTHER	PTHR37955	TELLURITE RESISTANCE PROTEIN TEHA
279	289	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
169	188	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
82	104	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
108	126	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
234	253	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
12	309	Pfam	PF03595	Voltage-dependent anion channel
12	309	InterPro	IPR004695	Transporter protein SLAC1/Mae1/ Ssu1/TehA
290	314	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
6	321	FunFam	G3DSA:1.50.10.150:FF:000002	Tellurite resistance protein TehA
223	233	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
154	181	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
85	102	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
12	31	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
143	165	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
13	316	NCBIfam	TIGR00816	tellurite-resistance/dicarboxylate transporter
13	316	InterPro	IPR011552	Tellurite resistance protein TehA/malic acid transport protein
103	107	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
108	130	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
294	316	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
14	303	CDD	cd09324	TDT_TehA
14	303	InterPro	IPR039264	Tellurite resistance protein TehA
201	223	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
233	250	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	11	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
257	279	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
201	222	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
65	84	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
315	334	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
32	42	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
182	200	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
259	278	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
7	321	Gene3D	G3DSA:1.50.10.150	-
7	321	InterPro	IPR038665	Voltage-dependent anion channel superfamily
48	70	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
254	258	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GTJ7	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_04449	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
16				0.983
1				0.94
24				0.713

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	15.97	0.767
2	15.59	0.757
3	9.46	0.509
4	5.55	0.266
5	4.32	0.179

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.953
8				0.883
20				0.332
24				0.312

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	20.75	0.861
2	17.45	0.802
3	12.8	0.662
4	6.84	0.351
5	5.85	0.286

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

53 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
BOG	3M7L	P44741	292.4 Da LogP 0.16 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)…`
PLC	7EN0	A0A0Q3IDG7	622.8 Da LogP 8.12 TPSA 108.4	2 viol.	✓ Clean	`CCCCCCCCCCCC(=O)OC[C@H](CO[P@](=O)(O)OCC[N+](C)…`
SPH	7EN0	A0A0Q3IDG7	299.5 Da LogP 3.92 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCCCC=C[C@@H]([C@@H](CO)N)O`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

Ligand	Tanimoto	MW · LogP · TPSA	Lipinski	PAINS	SMILES
ZINC100034925	1.000	348.5 Da LogP 1.72 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCCCCCO[C@@H]1O[C@@H](CO)[C@@H](O)[C@@H](…`
ZINC100056252	1.000	334.5 Da LogP 1.33 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[…`
ZINC100622854	1.000	348.5 Da LogP 1.72 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCCCCCO[C@H]1O[C@@H](CO)[C@@H](O)[C@@H](O…`
ZINC100622858	1.000	348.5 Da LogP 1.72 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCCCCCO[C@H]1O[C@@H](CO)[C@@H](O)[C@@H](O…`
ZINC100622862	1.000	348.5 Da LogP 1.72 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCCCCCO[C@@H]1O[C@@H](CO)[C@@H](O)[C@@H](…`
ZINC100623033	1.000	334.5 Da LogP 1.33 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCCCCO[C@H]1O[C@@H](CO)[C@@H](O)[C@@H](O)…`
ZINC100623036	1.000	334.5 Da LogP 1.33 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCCCCO[C@@H]1O[C@@H](CO)[C@@H](O)[C@@H](O…`
ZINC100623039	1.000	334.5 Da LogP 1.33 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCCCCO[C@H]1O[C@@H](CO)[C@@H](O)[C@@H](O)…`
ZINC118906329	1.000	348.5 Da LogP 1.72 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCCCCCO[C@H]1O[C@H](CO)[C@H](O)[C@@H](O)[…`
ZINC118906375	1.000	264.3 Da LogP -0.62 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCO[C@H]1O[C@H](CO)[C@H](O)[C@@H](O)[C@@H]1O`
ZINC118911500	1.000	278.3 Da LogP -0.23 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCO[C@H]1O[C@H](CO)[C@H](O)[C@@H](O)[C@@H]…`
ZINC13544781	1.000	482.6 Da LogP 4.22 TPSA 108.4	✓ Ro5	✓ Clean	`CCCCCCC(=O)OC[C@@H](CO[P@](=O)(O)OCC[N+](C)(C)C…`
ZINC13544783	1.000	482.6 Da LogP 4.22 TPSA 108.4	✓ Ro5	✓ Clean	`CCCCCCC(=O)OC[C@H](CO[P@](=O)(O)OCC[N+](C)(C)C)…`
ZINC140958235	1.000	348.5 Da LogP 1.72 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@H](O)[C@@H](O)…`
ZINC141152247	1.000	264.3 Da LogP -0.62 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCO[C@@H]1O[C@H](CO)[C@H](O)[C@@H](O)[C@@H]…`
ZINC14880350	1.000	306.4 Da LogP 0.55 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCCO[C@H]1O[C@@H](CO)[C@@H](O)[C@@H](O)[C…`
ZINC1903846766	1.000	299.5 Da LogP 3.92 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCCCC=C[C@H](O)[C@H](N)CO`
ZINC1903846767	1.000	299.5 Da LogP 3.92 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCCCC=C[C@@H](O)[C@H](N)CO`
ZINC1903846768	1.000	299.5 Da LogP 3.92 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCCCC=C[C@H](O)[C@@H](N)CO`
ZINC1903846769	1.000	299.5 Da LogP 3.92 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCCCC=C[C@@H](O)[C@@H](N)CO`
ZINC2296559890	1.000	285.5 Da LogP 3.53 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCCC=C[C@@H](O)[C@@H](N)CO`
ZINC2356543428	1.000	285.5 Da LogP 3.53 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCCC=C[C@@H](O)[C@H](N)CO`
ZINC2356543430	1.000	285.5 Da LogP 3.53 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCCC=C[C@H](O)[C@@H](N)CO`
ZINC2356543431	1.000	285.5 Da LogP 3.53 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCCC=C[C@H](O)[C@H](N)CO`
ZINC2574358	1.000	243.4 Da LogP 2.36 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCC/C=C/[C@H](O)[C@@H](N)CO`
ZINC299888723	1.000	243.4 Da LogP 2.36 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCC/C=C\[C@H](O)[C@@H](N)CO`
ZINC40165555	1.000	292.4 Da LogP 0.16 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H…`
ZINC43335325	1.000	215.3 Da LogP 1.58 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCC/C=C/[C@@H](O)[C@@H](N)CO`
ZINC4521560	1.000	264.3 Da LogP -0.62 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O`
ZINC48016017	1.000	278.3 Da LogP -0.23 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]…`
ZINC49780096	1.000	285.5 Da LogP 3.53 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO`
ZINC53683291	1.000	292.4 Da LogP 0.16 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]…`
ZINC58563863	1.000	292.4 Da LogP 0.16 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]…`
ZINC64858881	1.000	257.4 Da LogP 2.75 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCC/C=C/[C@H](O)[C@@H](N)CO`
ZINC64858886	1.000	257.4 Da LogP 2.75 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO`
ZINC64858887	1.000	285.5 Da LogP 3.53 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCC/C=C/[C@H](O)[C@@H](N)CO`
ZINC64858891	1.000	327.6 Da LogP 4.70 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCCCCC/C=C/[C@H](O)[C@@H](N)CO`
ZINC64858897	1.000	327.6 Da LogP 4.70 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO`
ZINC71788563	1.000	292.4 Da LogP 0.16 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCO[C@@H]1O[C@@H](CO)[C@@H](O)[C@H](O)[C@…`
ZINC72399366	1.000	243.4 Da LogP 2.36 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO`
ZINC8036008	1.000	299.5 Da LogP 3.92 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCCC/C=C\[C@@H](O)[C@@H](N)CO`
ZINC8195647	1.000	299.5 Da LogP 3.92 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCCC/C=C/[C@H](O)[C@H](N)CO`
ZINC8195648	1.000	299.5 Da LogP 3.92 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](N)CO`
ZINC8195649	1.000	299.5 Da LogP 3.92 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCCC/C=C/[C@H](O)[C@@H](N)CO`
ZINC8195650	1.000	299.5 Da LogP 3.92 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO`
ZINC85590876	1.000	320.4 Da LogP 0.94 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCCCO[C@@H]1O[C@@H](CO)[C@@H](O)[C@@H](O)…`
ZINC85605815	1.000	348.5 Da LogP 1.72 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCCCCCO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[…`
ZINC85892742	1.000	271.4 Da LogP 3.14 TPSA 66.5	✓ Ro5	✓ Clean	`CCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO`
ZINC94437834	1.000	292.4 Da LogP 0.16 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O`
ZINC95713698	1.000	348.5 Da LogP 1.72 TPSA 99.4	✓ Ro5	✓ Clean	`CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)…`

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.