Protein profile

KP13_04465

Inner membrane ABC transporter permease protein

Genome: KpKP13

Gene: AHE44339.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYN2
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Amino acids 309
Annotations 3
Features 34
PDB binders 0
Druggability 0.845

Overview

Basic information about this protein and its source genome.

Accession
KP13_04465
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44339.1
Status
annotated
Amino acids
309
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
88.963
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.57

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.845
Structure A0A0H3GYN2
Pocket Pocket 14
P2Rank 0.224
Structure A0A0H3GYN2
Pocket Pocket 1
ColabFold model
FPocket 0.847 · Pocket 14
P2Rank 0.22 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 71 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records
Show feature table
Start End DB Term Name
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
173 183 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
281 300 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
82 106 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
21 49 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
180 202 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
232 254 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
119 141 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
151 173 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
83 298 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
83 298 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
102 303 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
102 303 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
84 106 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
184 203 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
24 301 Gene3D G3DSA:1.10.3720.10 -
24 301 InterPro IPR035906 MetI-like superfamily
152 172 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
83 297 CDD cd06261 TM_PBP2
83 297 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
255 274 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
225 247 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
300 309 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
23 303 SUPERFAMILY SSF161098 MetI-like
23 303 InterPro IPR035906 MetI-like superfamily
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
107 117 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
252 271 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
50 81 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
118 140 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
141 151 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
275 299 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
204 231 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
19 304 PANTHER PTHR42929 INNER MEMBRANE ABC TRANSPORTER PERMEASE PROTEIN YDCU-RELATED-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYN2
AlphaFold — — full sequence — Viewing
ColabFold KP13_04465
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
14 0.845
1 0.813
7 0.692

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.62 0.135
2 3.41 0.123
3 2.07 0.046
4 1.32 0.015