Protein profile

KP13_04466

Inner membrane ABC transporter permease protein

Genome: KpKP13

Gene: AHE44340.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQI9
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Amino acids 268
Annotations 3
Features 31
PDB binders 0
Druggability 0.999

Overview

Basic information about this protein and its source genome.

Accession
KP13_04466
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44340.1
Status
annotated
Amino acids
268
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
89.313
DEG E-value
1.82e-149
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.52

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.999
Structure A0A0H3GQI9
Pocket Pocket 1
P2Rank 0.162
Structure A0A0H3GQI9
Pocket Pocket 1
ColabFold model
FPocket 0.826 · Pocket 10
P2Rank 0.207 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 70 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
128 132 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
103 127 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
234 256 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
80 247 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
80 247 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
132 154 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
154 188 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
180 202 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
257 268 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
189 212 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
71 93 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
7 261 FunFam G3DSA:1.10.3720.10:FF:000039 Inner membrane ABC transporter permease ydcV
213 231 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
5 260 SUPERFAMILY SSF161098 MetI-like
5 260 InterPro IPR035906 MetI-like superfamily
100 122 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
133 153 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
232 256 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
68 251 CDD cd06261 TM_PBP2
68 251 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
92 102 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
17 258 Gene3D G3DSA:1.10.3720.10 -
17 258 InterPro IPR035906 MetI-like superfamily
34 70 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
71 91 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
65 253 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
65 253 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
1 259 PANTHER PTHR43848 PUTRESCINE TRANSPORT SYSTEM PERMEASE PROTEIN POTI
12 33 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQI9
AlphaFold — — full sequence — Viewing
ColabFold KP13_04466
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.999
10 0.815
12 0.274

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.28 0.176
2 3.64 0.137
3 2.03 0.045
4 1.0 0.006