Protein profile

KP13_04478

putative HTH-type transcription

Genome: KpKP13

Gene: AHE44352.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYK3
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Amino acids 193
Annotations 3
Features 17
PDB binders 1
Druggability 0.13

Overview

Basic information about this protein and its source genome.

Accession
KP13_04478
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44352.1
Status
annotated
Amino acids
193
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
89.81

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.13
Structure A0A0H3GYK3
Pocket Pocket 1
P2Rank 0.651
Structure A0A0H3GYK3
Pocket Pocket 1
ColabFold model
FPocket 0.634 · Pocket 1
P2Rank 0.599 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 59 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
16 70 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
16 70 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
55 187 SUPERFAMILY SSF51182 RmlC-like cupins
55 187 InterPro IPR011051 RmlC-like cupin domain superfamily
16 69 Pfam PF01381 Helix-turn-helix
16 69 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
10 184 PANTHER PTHR46797 HTH-TYPE TRANSCRIPTIONAL REGULATOR
86 191 Gene3D G3DSA:2.60.120.10 Jelly Rolls
86 191 InterPro IPR014710 RmlC-like jelly roll fold
8 74 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
8 74 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
97 184 CDD cd02209 cupin_XRE_C
15 70 CDD cd00093 HTH_XRE
15 70 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
3 80 Gene3D G3DSA:1.10.260.40 -
3 80 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
15 70 SMART SM00530 mbf_short4

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYK3
AlphaFold — — full sequence — Viewing
ColabFold KP13_04478
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.27 0.603
2 1.46 0.02

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
MED
1Y9Q
Q9KQN0 149.2 Da LogP 0.15 TPSA 63.3 ✓ Ro5 ✓ Clean CSCC[C@H](C(=O)O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.