KpKP13 Protein target profile

Sucrose porin

Accession: KP13_04500

Gene: AHE44374.1 3D evidence: AlphaFold DB model + ColabFold model UniProt A0A0H3GU23
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Length 538
Pocket druggability (P2Rank · AlphaFold DB model) 0.819
Functional annotation 0 EC 8 GO
Target summary

Promising target candidate with multiple supporting evidence streams.

Automated synthesis of the evidence currently loaded. Review the underlying records before prioritizing this protein.

Main supporting evidence

Independent pocket support: P2Rank + FPocket Both predictors report a high-scoring binding site (P2Rank 0.82, FPocket 0.84). Use the 3D pocket comparison to verify whether they identify the same site. No similar human protein detected The current BLAST sequence screen did not find a significant human match, lowering apparent off-target risk. Strong predicted binding pocket FPocket selected-pocket score 0.84. This is a computational pocket signal, not binding validation. Second pocket predictor agrees P2Rank predicted binding-site probability 0.82. Review the complete evidence below

Risks to review

Microbiome similarity 13 of 4744 screened genomes (0.3%) have a significant similarity hit. This target also has a predicted binding pocket (P2Rank 0.82) — check the ligand evidence before deprioritizing on off-target risk alone. Mixed conservation Core/accessory calls are not fully concordant.

Evidence gaps

No metabolic context No SBML/network-derived reaction evidence is loaded for this protein. No ligand evidence No experimental PDB ligands, measured ChEMBL bioactivity, or proposed ZINC compound records are available.
Terms and data sources used on this page

PDB: experimentally determined structures from the Protein Data Bank. These are the strongest structural evidence, but may cover only part of the protein.

AlphaFold DB model: a precomputed predicted structure downloaded from AlphaFold Database/UniProt, not an experiment performed here.

ColabFold model: a predicted structure generated for this workspace; interpret it with coverage and confidence.

pLDDT: confidence score for predicted structures. High values support local geometry; low values mean the region should not drive pocket interpretation.

FPocket / P2Rank: software tools that predict possible ligand-binding pockets on a 3D structure. They are useful screening signals, not experimental validation.

Druggability: a pocket-based estimate of whether a small molecule could bind productively. It does not mean a drug already exists.

PDB ligand: a compound observed in an experimental structure. Direct same-protein records are stronger than homolog-transferred records.

ChEMBL: a public database of measured compound bioactivity. Direct entries are stronger than entries transferred from similar proteins.

ZINC: a purchasable-compound database. Here it marks proposed candidates from chemical similarity, not measured binders.

LigQ / LigQ_2: an internal Target pipeline step that gathers PDB, ChEMBL, and ZINC ligand evidence for each protein.

Off-target: sequence similarity to proteins we prefer not to hit, such as human proteins or beneficial gut microbiome proteins.

DEG: Database of Essential Genes. A match suggests the protein resembles genes known to be essential in other organisms.

Roary / CoreCruncher: pan-genome tools used to decide whether a gene is core across analyzed strains or accessory/strain-specific.

EC / GO: functional annotations: EC describes enzyme reactions; GO describes biological process, molecular function, or cellular component.

KEGG pathway: a curated metabolic route label used here to group reactions imported from the metabolic model.

Chokepoint: a metabolic reaction that is the only producer or consumer of a metabolite in the imported model.

Prioritization evidence

Selectivity, essentiality, structural confidence, conservation, and predicted binding-site evidence.

Off-target risk

Human off-target
No hit
Gut microbiome similarity
0.3% of screened genomes Lower prevalence suggests narrower overlap with the screened gut microbiome.

Essentiality

Essential (DEG)
N
DEG identity (%)
0.0 Higher values support similarity to known essential genes.

Structure confidence

ColabFold pLDDT
87.68 0-100 confidence; >70 supports local structural interpretation.

Binding-site evidence

AlphaFold DB / UniProt model

P2Rank's binding-site probability is the primary druggability signal shown across the app; FPocket's druggability score is shown alongside it for comparison. Both estimate small-molecule pocket quality after applying the curated structure priority — neither is experimental binding evidence. The 3D viewer may show a different loaded structure, so visible pockets can differ.

Druggability (P2Rank) 0.819
Structure A0A0H3GU23
Pocket Pocket 1
Druggability (FPocket) 0.839
Structure A0A0H3GU23
Pocket Pocket 12
ColabFold model
P2Rank 0.708 · Pocket 1
FPocket 0.925 · Pocket 5
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 13 / 4744 genomes with a hit
Prevalence 0.3%

Sequence

Primary amino-acid sequence viewer.

MRISVISAAVCCALFPLISVSAAGLSVEQRLAQLEARLNLAEQQASEASRRAQRAEQQTAAAEQRAAAAEQQVQALSQQTTAREQKQQATNQQLSEQLAKRAPDDGFTFNAYARSGMLVNSHGKGARGGPGVSPASSLNGDAHVGRLGNEKDNYAELSFGKKLTFNDGSWARFKTMLADGATNPDPWVQDNDSHHLNIRQLYVEMGNFAEFTGPLKRASIWAGKRFDRDNFDIHFTDSDIMFLGGTGGGINDVDWGSGLRGDYSVYARNFGDLGSDNYADNDIQNLLFTANHFYGNWQLMTTVMTAQGNDDLKDNTSTTGSYALRSDNTAKNGYYAMLALHDKQQFYGLAPGVSESALQYGVGLGAEARQPGSDGDLTENAASLRFASYGILPLGKNWQLAPSVIAQHSEDRYRDGDRYDWATFNLRVSQGISAHFALLYEASWQYMDLNPNGRSYRYNDNVYQYQAVRGDFYKLTFAPTFKVGDVLDIKARPEIRFFATWMNWDKALDRYAINDDFGSKGFTAGGTWNFGVQTEIWF

Functional annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Subcellular localization

Localization
OuterMembrane

Gene Ontology (GO)

8
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0034219 The process in which a carbohydrate is transported across a membrane.
  • GO:0015288 Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0046930 A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids.
  • GO:0015144 Enables the transfer of carbohydrate from one side of a membrane to the other.
  • GO:0006811 The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
  • GO:0015774 The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.

Sequence domains and features

Domain and signature matches imported from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
122 144 MobiDBLite mobidb-lite consensus disorder prediction
72 100 MobiDBLite mobidb-lite consensus disorder prediction
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
19 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
109 538 Pfam PF02264 LamB porin
109 538 InterPro IPR003192 Porin, LamB-type
106 538 SUPERFAMILY SSF56935 Porins
23 538 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
26 56 Pfam PF11471 Maltoporin periplasmic N-terminal extension
26 56 InterPro IPR021570 LamB-type porin N-terminal domain
108 538 PANTHER PTHR38762 CRYPTIC OUTER MEMBRANE PORIN BGLH-RELATED
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
27 96 SUPERFAMILY SSF57997 Tropomyosin
105 538 Gene3D G3DSA:2.40.170.10 Porin, LamB type
105 538 InterPro IPR036998 Porin, LamB-type superfamily
24 79 Coils Coil Coil
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
72 98 MobiDBLite mobidb-lite consensus disorder prediction
3 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; AlphaFold DB and ColabFold models typically cover the full protein but remain computational predictions.

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Pocket score High Medium Low
How colors and pocket overlays are used
Uniform protein color marks the displayed model as a single molecular object.
Experimental PDB structures may be colored by chain to distinguish subunits or copies present in the file.
Pocket colors and alpha spheres are evidence overlays for predicted binding cavities; they are not alternative protein chains.
'Alpha spheres' is FPocket's own cavity-shape geometry, imported when available and aligned with the loaded structure.
'Pocket atoms'/'Predicted site atoms' show the pocket's residue atoms instead: P2Rank reports residues rather than alpha spheres, and FPocket falls back to this when alpha-sphere geometry is unavailable or doesn't align.
'No pocket geometry' means neither alpha spheres nor residue-position data could be found for that pocket; the layer just highlights the same residues as 'Nearby residues'.
Pocket details Inspect a specific pocket, or open the full viewer

Binding pockets · P2Rank

Druggability (P2Rank): high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Pocket 1 P2Rank #1
0.819
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Surrounding area
Pocket 2 P2Rank #2
0.245
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Surrounding area
Pocket 3 P2Rank #3
0.082
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Surrounding area
Pocket 4 P2Rank #4
0.061
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Surrounding area
Pocket 5 P2Rank #5
0.038
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Surrounding area

Binding pockets · FPocket

Druggability (FPocket): high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Pocket 1 FPocket #12
0.839 Unusual size
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Surrounding area
Pocket 2 FPocket #7
0.557
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Surrounding area
All structural evidence 0 experimental · 2 predicted

Structural evidence

0 + 2

Experimental PDB entries plus predicted AlphaFold DB or ColabFold models. Click Switch to display a different loaded structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold DB AF_A0A0H3GU23
AlphaFold DB — — full sequence — Viewing
ColabFold KP13_04500
ColabFold — — full sequence — Loaded

Cross-references

External database identifiers for this protein, its structures, ligands, and metabolic reactions.

Sequence

UniProt A0A0H3GU23