Protein profile

KP13_04500

Sucrose porin

Genome: KpKP13

Gene: AHE44374.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GU23
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Amino acids 538
Annotations 8
Features 21
PDB binders 0
Druggability 0.839

Overview

Basic information about this protein and its source genome.

Accession
KP13_04500
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44374.1
Status
annotated
Amino acids
538
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034219 The process in which a carbohydrate is transported across a membrane. GO:0015288 Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0046930 A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids. GO:0015144 Enables the transfer of carbohydrate from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
87.68

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.839
Structure A0A0H3GU23
Pocket Pocket 12
P2Rank 0.819
Structure A0A0H3GU23
Pocket Pocket 1
ColabFold model
FPocket 0.925 · Pocket 5
P2Rank 0.708 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 13 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0034219 The process in which a carbohydrate is transported across a membrane.
  • GO:0015288 Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0046930 A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids.
  • GO:0015144 Enables the transfer of carbohydrate from one side of a membrane to the other.
  • GO:0006811 The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
  • GO:0015774 The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
122 144 MobiDBLite mobidb-lite consensus disorder prediction
72 100 MobiDBLite mobidb-lite consensus disorder prediction
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
19 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
109 538 Pfam PF02264 LamB porin
109 538 InterPro IPR003192 Porin, LamB-type
106 538 SUPERFAMILY SSF56935 Porins
23 538 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
26 56 Pfam PF11471 Maltoporin periplasmic N-terminal extension
26 56 InterPro IPR021570 LamB-type porin N-terminal domain
108 538 PANTHER PTHR38762 CRYPTIC OUTER MEMBRANE PORIN BGLH-RELATED
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
27 96 SUPERFAMILY SSF57997 Tropomyosin
105 538 Gene3D G3DSA:2.40.170.10 Porin, LamB type
105 538 InterPro IPR036998 Porin, LamB-type superfamily
24 79 Coils Coil Coil
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
72 98 MobiDBLite mobidb-lite consensus disorder prediction
3 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GU23
AlphaFold — — full sequence — Viewing
ColabFold KP13_04500
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.839
7 0.557

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.3 0.605
2 3.52 0.129
3 3.04 0.1
4 1.77 0.032
5 0.98 0.005