Protein profile

KP13_04502

putative sugar hydrolase

Genome: KpKP13

Gene: AHE44376.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYF9
Export view
Amino acids 510
Annotations 2
Features 7
PDB binders 0
Druggability 0.617

Overview

Basic information about this protein and its source genome.

Accession
KP13_04502
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44376.1
Status
annotated
Amino acids
510
Structure source
AlphaFold + ColabFold
GO
GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.72

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.617
Structure A0A0H3GYF9
Pocket Pocket 2
P2Rank 0.941
Structure A0A0H3GYF9
Pocket Pocket 1
ColabFold model
FPocket 0.49 · Pocket 1
P2Rank 0.861 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 13 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
61 508 PANTHER PTHR34987 C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED
180 505 Pfam PF17389 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain
180 505 InterPro IPR035396 Alpha-L-rhamnosidase, six-hairpin glycosidase domain
207 508 SUPERFAMILY SSF48208 Six-hairpin glycosidases
207 508 InterPro IPR008928 Six-hairpin glycosidase superfamily
180 507 Gene3D G3DSA:1.50.10.10 -
180 507 InterPro IPR012341 Six-hairpin glycosidase-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYF9
AlphaFold — — full sequence — Viewing
ColabFold KP13_04502
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.001
10 0.001
15 0.001
26 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 37.92 0.941
2 8.72 0.398
3 6.02 0.246
4 4.48 0.157
5 4.15 0.138