Protein profile

KP13_04503

HTH-type transcriptional activator rhaS

Genome: KpKP13

Gene: AHE44377.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQE5
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Amino acids 274
Annotations 3
Features 24
PDB binders 0
Druggability 0.176

Overview

Basic information about this protein and its source genome.

Accession
KP13_04503
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44377.1
Status
annotated
Amino acids
274
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.11

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.176
Structure A0A0H3GQE5
Pocket Pocket 12
P2Rank 0.552
Structure A0A0H3GQE5
Pocket Pocket 1
ColabFold model
FPocket 0.784 · Pocket 6
P2Rank 0.459 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 10 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
27 272 PANTHER PTHR46796 HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAS-RELATED
222 271 SUPERFAMILY SSF46689 Homeodomain-like
222 271 InterPro IPR009057 Homeobox-like domain superfamily
221 265 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature.
221 265 InterPro IPR018062 HTH domain AraC-type, conserved site
192 271 Pfam PF12833 Helix-turn-helix domain
192 271 InterPro IPR018060 DNA binding HTH domain, AraC-type
170 272 Gene3D G3DSA:1.10.10.60 -
253 269 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
253 269 InterPro IPR020449 Transcription regulator HTH, AraC- type
238 253 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
238 253 InterPro IPR020449 Transcription regulator HTH, AraC- type
20 103 Pfam PF02311 AraC-like ligand binding domain
20 103 InterPro IPR003313 AraC-type arabinose-binding/dimerisation domain
171 220 SUPERFAMILY SSF46689 Homeodomain-like
171 220 InterPro IPR009057 Homeobox-like domain superfamily
10 99 Gene3D G3DSA:2.60.120.10 Jelly Rolls
10 99 InterPro IPR014710 RmlC-like jelly roll fold
186 269 SMART SM00342 aracneu4
186 269 InterPro IPR018060 DNA binding HTH domain, AraC-type
19 156 SUPERFAMILY SSF51215 Regulatory protein AraC
19 156 InterPro IPR037923 Transcription regulator HTH-like
173 271 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
173 271 InterPro IPR018060 DNA binding HTH domain, AraC-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQE5
AlphaFold — — full sequence — Viewing
ColabFold KP13_04503
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.92 0.421
2 3.43 0.123
3 1.62 0.026