Protein profile

KP13_04507

Ferric transport system permease protein fbpB

Genome: KpKP13

Gene: fbpB AHE44381.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYE5

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Amino acids 570

Annotations 3

Features 60

PDB binders 0

Druggability 0.924

Overview

Basic information about this protein and its source genome.

Accession: KP13_04507
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: fbpB AHE44381.1
Status: annotated
Amino acids: 570
Structure source: AlphaFold + ColabFold

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 0.0
Localization: CytoplasmicMembrane
ColabFold pLDDT: 89.43

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.924

Structure A0A0H3GYE5

Pocket Pocket 6

P2Rank 0.807

Structure A0A0H3GYE5

Pocket Pocket 1

ColabFold model

FPocket 0.968 · Pocket 2

P2Rank 0.828 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 24 / 4744 genomes with a hit

Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

60 records

Show feature table

Start	End	DB	Term	Name
457	483	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
258	280	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	23	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
155	177	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
281	304	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
103	113	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
78	277	ProSiteProfiles	PS50928	ABC transporter integral membrane type-1 domain profile.
78	277	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
204	226	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
260	280	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
406	427	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
27	288	Gene3D	G3DSA:1.10.3720.10	-
27	288	InterPro	IPR035906	MetI-like superfamily
24	284	SUPERFAMILY	SSF161098	MetI-like
24	284	InterPro	IPR035906	MetI-like superfamily
202	227	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
371	393	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
178	201	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
507	511	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
114	135	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
51	81	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
308	566	SUPERFAMILY	SSF161098	MetI-like
308	566	InterPro	IPR035906	MetI-like superfamily
543	564	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
372	394	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
484	506	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
439	456	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
115	137	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
310	332	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
406	428	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
80	102	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
438	460	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
368	555	CDD	cd06261	TM_PBP2
368	555	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
28	565	PANTHER	PTHR43357	INNER MEMBRANE ABC TRANSPORTER PERMEASE PROTEIN YDCV
428	438	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
487	509	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
136	154	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
305	329	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
228	259	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
368	562	ProSiteProfiles	PS50928	ABC transporter integral membrane type-1 domain profile.
368	562	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
385	564	Pfam	PF00528	Binding-protein-dependent transport system inner membrane component
385	564	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
96	284	Pfam	PF00528	Binding-protein-dependent transport system inner membrane component
96	284	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
24	50	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
78	238	CDD	cd06261	TM_PBP2
78	238	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
565	570	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
161	183	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
395	405	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
512	531	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
308	569	Gene3D	G3DSA:1.10.3720.10	-
308	569	InterPro	IPR035906	MetI-like superfamily
542	564	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
532	542	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
24	46	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
330	371	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
82	102	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GYE5	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_04507	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
6				0.924
2				0.754
26				0.22
11				0.205

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	15.44	0.753
2	5.49	0.261
3	2.62	0.076
4	2.22	0.054
5	2.21	0.053

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.968
37				0.543
31				0.205

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	16.44	0.779
2	5.38	0.255
3	2.71	0.081
4	2.6	0.075
5	2.55	0.072