Protein profile

KP13_04510

Respiratory nitrate reductase 2 delta chain

Genome: KpKP13

Gene: narW AHE44386.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GU16
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Amino acids 231
Annotations 4
Features 9
PDB binders 0
Druggability 0.868

Overview

Basic information about this protein and its source genome.

Accession
KP13_04510
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
narW AHE44386.1
Status
annotated
Amino acids
231
Structure source
AlphaFold + ColabFold
GO
GO:0051131 The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. GO:0051082 Binding to an unfolded protein. GO:0016530 Binding to and delivering metal ions to a target protein. GO:0042128 The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
58.723
DEG E-value
8.599999999999999e-90
Localization
Cytoplasmic
ColabFold pLDDT
85.56

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.868
Structure A0A0H3GU16
Pocket Pocket 1
P2Rank 0.462
Structure A0A0H3GU16
Pocket Pocket 1
ColabFold model
FPocket 0.649 · Pocket 13
P2Rank 0.451 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 95 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0051131 The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.
  • GO:0051082 Binding to an unfolded protein.
  • GO:0016530 Binding to and delivering metal ions to a target protein.
  • GO:0042128 The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
6 145 Gene3D G3DSA:1.10.3480.10 -
3 229 PANTHER PTHR43680 NITRATE REDUCTASE MOLYBDENUM COFACTOR ASSEMBLY CHAPERONE
3 229 InterPro IPR003765 Nitrate reductase chaperone, NarJ
2 157 SUPERFAMILY SSF89155 TorD-like
2 157 InterPro IPR036411 TorD-like superfamily
9 154 NCBIfam TIGR00684 nitrate reductase molybdenum cofactor assembly chaperone
9 154 InterPro IPR003765 Nitrate reductase chaperone, NarJ
33 150 Pfam PF02613 Nitrate reductase delta subunit
33 150 InterPro IPR020945 DMSO/Nitrate reductase chaperone

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GU16
AlphaFold — — full sequence — Viewing
ColabFold KP13_04510
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.868
17 0.502

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.86 0.417
2 2.31 0.059