Protein profile

KP13_04521

Benzoate 1,2-dioxygenase subunit beta

Genome: KpKP13

Gene: AHE44397.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYB6
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Amino acids 161
Annotations 3
Features 11
PDB binders 0
Druggability 0.109

Overview

Basic information about this protein and its source genome.

Accession
KP13_04521
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44397.1
Status
annotated
Amino acids
161
Structure source
AlphaFold + ColabFold
GO
GO:0006725 OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. GO:0051213 Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. GO:0019380 The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.109
Structure A0A0H3GYB6
Pocket Pocket 4
P2Rank 0.007
Structure A0A0H3GYB6
Pocket Pocket 1
ColabFold model
FPocket 0.74 · Pocket 1
P2Rank 0.118 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 33 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006725 OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
  • GO:0051213 Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate.
  • GO:0019380 The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
4 159 PANTHER PTHR41534 BLR3401 PROTEIN
4 159 InterPro IPR000391 Ring-hydroxylating dioxygenase beta subunit
4 161 SUPERFAMILY SSF54427 NTF2-like
4 161 InterPro IPR032710 NTF2-like domain superfamily
1 161 Gene3D G3DSA:3.10.450.50 -
6 160 CDD cd00667 ring_hydroxylating_dioxygenases_beta
6 160 InterPro IPR000391 Ring-hydroxylating dioxygenase beta subunit
14 153 Pfam PF00866 Ring hydroxylating beta subunit
14 153 InterPro IPR000391 Ring-hydroxylating dioxygenase beta subunit
7 161 NCBIfam TIGR03232 benzoate 1,2-dioxygenase small subunit
7 161 InterPro IPR017641 Benzoate 1,2-dioxygenase, small subunit

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYB6
AlphaFold — — full sequence — Viewing
ColabFold KP13_04521
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.05 0.006
2 0.67 0.001