Protein profile

KP13_04530

hypothetical protein

Genome: KpKP13

Gene: AHE44405.1 Structure source: AlphaFold + ColabFold UniProt W8UJV5
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Amino acids 85
Annotations 2
Features 5
PDB binders 0
Druggability 0.119

Overview

Basic information about this protein and its source genome.

Accession
KP13_04530
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44405.1
Status
annotated
Amino acids
85
Structure source
AlphaFold + ColabFold
GO
GO:0006276 The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division. GO:0008657 Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
92.31

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.119
Structure W8UJV5
Pocket Pocket 1
P2Rank 0.067
Structure W8UJV5
Pocket Pocket 1
ColabFold model
FPocket 0.102 · Pocket 1
P2Rank 0.054 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 9 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006276 The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division.
  • GO:0008657 Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
2 83 SUPERFAMILY SSF50118 Cell growth inhibitor/plasmid maintenance toxic component
1 85 Gene3D G3DSA:2.30.30.110 -
1 85 InterPro IPR011067 Plasmid maintenance toxin/Cell growth inhibitor
1 83 Pfam PF01845 CcdB protein
1 83 InterPro IPR002712 Toxin CcdB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_W8UJV5
AlphaFold — — full sequence — Viewing
ColabFold KP13_04530
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.01 0.043