Protein profile

KP13_04536

hypothetical protein

Genome: KpKP13

Gene: AHE44411.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTC5
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Amino acids 363
Annotations 1
Features 17
PDB binders 0
Druggability 0.562

Overview

Basic information about this protein and its source genome.

Accession
KP13_04536
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44411.1
Status
annotated
Amino acids
363
Structure source
AlphaFold + ColabFold
GO
GO:0051920 Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
96.81

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.562
Structure A0A0H3GTC5
Pocket Pocket 4
P2Rank 0.886
Structure A0A0H3GTC5
Pocket Pocket 1
ColabFold model
FPocket 0.854 · Pocket 1
P2Rank 0.91 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 28 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0051920 Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
215 360 PANTHER PTHR35446 SI:CH211-175M2.5
195 360 NCBIfam TIGR01926 peroxidase-related enzyme
195 360 InterPro IPR010195 Uncharacterised peroxidase-related
189 363 Gene3D G3DSA:1.20.1290.10 -
189 363 InterPro IPR029032 AhpD-like
225 288 Pfam PF02627 Carboxymuconolactone decarboxylase family
225 288 InterPro IPR003779 Carboxymuconolactone decarboxylase-like
174 360 NCBIfam TIGR04030 alkylhydroperoxidase domain protein
174 360 InterPro IPR023923 Alkylhydroperoxidase domain-containing protein, Avi7169
19 144 SUPERFAMILY SSF69118 AhpD-like
19 144 InterPro IPR029032 AhpD-like
3 148 Gene3D G3DSA:1.20.1290.10 -
3 148 InterPro IPR029032 AhpD-like
241 288 NCBIfam TIGR00778 alkylhydroperoxidase AhpD family core domain
241 288 InterPro IPR004675 Alkylhydroperoxidase AhpD core
182 360 SUPERFAMILY SSF69118 AhpD-like
182 360 InterPro IPR029032 AhpD-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTC5
AlphaFold — — full sequence — Viewing
ColabFold KP13_04536
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.558
8 0.049
5 0.026
3 0.002

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 27.93 0.886
2 2.87 0.073
3 1.83 0.029
4 1.34 0.013
5 0.85 0.003