Protein profile

KP13_04539

putative D,D-dipeptide transport system permease protein ddpC

Genome: KpKP13

Gene: ddpC AHE44414.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GY92
Export view
Amino acids 282
Annotations 3
Features 30
PDB binders 0
Druggability 0.842

Overview

Basic information about this protein and its source genome.

Accession
KP13_04539
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ddpC AHE44414.1
Status
annotated
Amino acids
282
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.91

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.842
Structure A0A0H3GY92
Pocket Pocket 6
P2Rank 0.404
Structure A0A0H3GY92
Pocket Pocket 1
ColabFold model
FPocket 0.98 · Pocket 24
P2Rank 0.271 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 47 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
144 148 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
232 250 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
103 273 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
103 273 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
149 167 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
78 267 SUPERFAMILY SSF161098 MetI-like
78 267 InterPro IPR035906 MetI-like superfamily
251 271 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
205 231 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
272 282 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
85 274 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
85 274 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
127 149 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
76 278 Gene3D G3DSA:1.10.3720.10 -
76 278 InterPro IPR035906 MetI-like superfamily
124 143 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
92 114 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
113 123 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
168 204 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
182 199 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
206 228 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
21 41 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
89 112 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
42 88 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
248 270 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
14 275 PANTHER PTHR43386 OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC
85 252 CDD cd06261 TM_PBP2
85 252 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GY92
AlphaFold — — full sequence — Viewing
ColabFold KP13_04539
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.842

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.59 0.459
2 6.21 0.31
3 1.21 0.011