Protein profile

KP13_04545

HTH-type DNA-binding domain-containing acetyltransferase

Genome: KpKP13

Gene: AHE44420.1 Structure source: AlphaFold + ColabFold UniProt W8UUM9
Export view
Amino acids 301
Annotations 4
Features 25
PDB binders 0
Druggability 0.957

Overview

Basic information about this protein and its source genome.

Accession
KP13_04545
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44420.1
Status
annotated
Amino acids
301
Structure source
AlphaFold + ColabFold
GO
GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0008080 Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
30.172
Human E-value
2.1e-06
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
87.26

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.957
Structure W8UUM9
Pocket Pocket 1
P2Rank 0.948
Structure W8UUM9
Pocket Pocket 1
ColabFold model
FPocket 0.976 · Pocket 1
P2Rank 0.949 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 24 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0008080 Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
140 290 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
140 290 InterPro IPR000182 GNAT domain
146 286 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
146 286 InterPro IPR016181 Acyl-CoA N-acyltransferase
18 74 Pfam PF12802 MarR family
18 74 InterPro IPR000835 MarR-type HTH domain
51 66 PRINTS PR00598 Bacterial regulatory protein MarR family signature
51 66 InterPro IPR000835 MarR-type HTH domain
70 86 PRINTS PR00598 Bacterial regulatory protein MarR family signature
70 86 InterPro IPR000835 MarR-type HTH domain
34 50 PRINTS PR00598 Bacterial regulatory protein MarR family signature
34 50 InterPro IPR000835 MarR-type HTH domain
8 127 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
8 127 InterPro IPR036390 Winged helix DNA-binding domain superfamily
193 257 CDD cd04301 NAT_SF
10 110 SMART SM00347 marrlong4
10 110 InterPro IPR000835 MarR-type HTH domain
3 137 Gene3D G3DSA:1.10.10.10 -
3 137 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
148 284 Gene3D G3DSA:3.40.630.30 -
1 122 ProSiteProfiles PS50995 MarR-type HTH domain profile.
1 122 InterPro IPR000835 MarR-type HTH domain
153 288 PANTHER PTHR13947 GNAT FAMILY N-ACETYLTRANSFERASE
177 274 Pfam PF00583 Acetyltransferase (GNAT) family
177 274 InterPro IPR000182 GNAT domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_W8UUM9
AlphaFold — — full sequence — Viewing
ColabFold KP13_04545
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.957
17 0.248
21 0.215

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 30.96 0.937
2 3.09 0.104