Protein profile

KP13_04569

hypothetical protein

Genome: KpKP13

Gene: AHE44444.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTW4
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Amino acids 228
Annotations 0
Features 9
PDB binders 0
Druggability 0.43

Overview

Basic information about this protein and its source genome.

Accession
KP13_04569
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44444.1
Status
annotated
Amino acids
228
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
95.08

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.43
Structure A0A0H3GTW4
Pocket Pocket 8
P2Rank 0.419
Structure A0A0H3GTW4
Pocket Pocket 1
ColabFold model
FPocket 0.437 · Pocket 12
P2Rank 0.433 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 16 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
25 220 PANTHER PTHR35936 MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE F
8 214 Gene3D G3DSA:3.40.190.10 -
9 226 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
94 181 Gene3D G3DSA:3.40.190.10 -
8 227 SMART SM00062 AABind_6
8 227 InterPro IPR001638 Solute-binding protein family 3/N-terminal domain of MltF
22 225 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3
22 225 InterPro IPR001638 Solute-binding protein family 3/N-terminal domain of MltF
4 223 CDD cd13623 PBP2_AA_hypothetical

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTW4
AlphaFold — — full sequence — Viewing
ColabFold KP13_04569
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.43

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.38 0.321
2 0.79 0.002