Protein profile

KP13_04577

virulence factor MgtC protein

Genome: KpKP13

Gene: mgtC AHE44452.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTV5
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Amino acids 236
Annotations 2
Features 28
PDB binders 0
Druggability 0.965

Overview

Basic information about this protein and its source genome.

Accession
KP13_04577
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
mgtC AHE44452.1
Status
annotated
Amino acids
236
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
83.59

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.965
Structure A0A0H3GTV5
Pocket Pocket 1
P2Rank 0.063
Structure A0A0H3GTV5
Pocket Pocket 1
ColabFold model
FPocket 0.951 · Pocket 1
P2Rank 0.076 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 46 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
1 11 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
41 60 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
93 117 PRINTS PR01837 MgtC/SapB protein signature
93 117 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
66 88 PRINTS PR01837 MgtC/SapB protein signature
66 88 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
41 59 PRINTS PR01837 MgtC/SapB protein signature
41 59 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
22 41 PRINTS PR01837 MgtC/SapB protein signature
22 41 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
112 116 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
147 236 Gene3D G3DSA:3.30.70.260 -
93 111 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
10 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
70 87 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
135 236 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
99 118 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
87 92 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
68 86 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 30 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
63 67 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
117 134 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
42 62 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
15 233 PANTHER PTHR33778 PROTEIN MGTC
15 233 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
19 138 Pfam PF02308 MgtC family
19 138 InterPro IPR003416 MgtC/SapB/SrpB/YhiD family
31 41 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTV5
AlphaFold — — full sequence — Viewing
ColabFold KP13_04577
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.965

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.06 0.046