Protein profile

KP13_05469

putative ABC transporter permease protein

Genome: KpKP13

Gene: AHE44474.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GT47
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Amino acids 246
Annotations 3
Features 29
PDB binders 0
Druggability 0.712

Overview

Basic information about this protein and its source genome.

Accession
KP13_05469
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44474.1
Status
annotated
Amino acids
246
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
51.429
DEG E-value
5.37e-72
Localization
CytoplasmicMembrane
ColabFold pLDDT
94.01

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.712
Structure A0A0H3GT47
Pocket Pocket 3
P2Rank 0.023
Structure A0A0H3GT47
Pocket Pocket 1
ColabFold model
FPocket 0.514 · Pocket 14
P2Rank 0.018 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 41 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records
Show feature table
Start End DB Term Name
10 245 PANTHER PTHR30151 ALKANE SULFONATE ABC TRANSPORTER-RELATED, MEMBRANE SUBUNIT
40 54 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
81 86 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
214 233 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
119 138 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
234 246 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
87 113 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
113 135 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
22 39 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
49 237 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
49 237 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
49 205 CDD cd06261 TM_PBP2
49 205 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
58 80 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
67 238 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
67 238 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
214 233 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
55 80 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
39 241 Gene3D G3DSA:1.10.3720.10 -
39 241 InterPro IPR035906 MetI-like superfamily
139 213 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
87 109 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
48 233 SUPERFAMILY SSF161098 MetI-like
48 233 InterPro IPR035906 MetI-like superfamily
114 118 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 39 Phobius SIGNAL_PEPTIDE Signal peptide region
11 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GT47
AlphaFold — — full sequence — Viewing
ColabFold KP13_05469
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.712
17 0.297
8 0.233
9 0.22

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.04 0.045
2 1.42 0.018
3 0.85 0.003