Protein profile

KP13_05476

Lambda repressor-like, DNA-binding domain-containing protein

Genome: KpKP13

Gene: AHE44481.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNM9
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Amino acids 346
Annotations 5
Features 21
PDB binders 0
Druggability 0.847

Overview

Basic information about this protein and its source genome.

Accession
KP13_05476
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44481.1
Status
annotated
Amino acids
346
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0030246 Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.847
Structure A0A0H3GNM9
Pocket Pocket 1
P2Rank 0.86
Structure A0A0H3GNM9
Pocket Pocket 1
ColabFold model
FPocket 0.271 · Pocket 1
P2Rank 0.861 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 9 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0030246 Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
113 337 Gene3D G3DSA:3.40.50.2300 -
2 64 Gene3D G3DSA:1.10.260.40 -
2 64 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
174 346 Gene3D G3DSA:3.40.50.2300 -
8 62 ProSiteProfiles PS50932 LacI-type HTH domain profile.
8 62 InterPro IPR000843 LacI-type HTH domain
67 345 PANTHER PTHR30036 D-XYLOSE-BINDING PERIPLASMIC PROTEIN
7 80 SMART SM00354 laci3
7 80 InterPro IPR000843 LacI-type HTH domain
70 343 CDD cd06307 PBP1_sugar_binding
9 52 Pfam PF00356 Bacterial regulatory proteins, lacI family
9 52 InterPro IPR000843 LacI-type HTH domain
68 342 SUPERFAMILY SSF53822 Periplasmic binding protein-like I
68 342 InterPro IPR028082 Periplasmic binding protein-like I
11 52 CDD cd01392 HTH_LacI
11 52 InterPro IPR000843 LacI-type HTH domain
115 324 Pfam PF13407 Periplasmic binding protein domain
115 324 InterPro IPR025997 Periplasmic binding protein
10 28 ProSitePatterns PS00356 LacI-type HTH domain signature.
7 63 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
7 63 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNM9
AlphaFold — — full sequence — Viewing
ColabFold KP13_05476
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.847

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.31 0.8