Protein profile

KP13_05481

Transcriptional regulator, GntR family

Genome: KpKP13

Gene: AHE44486.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTR8
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Amino acids 238
Annotations 3
Features 21
PDB binders 0
Druggability 0.412

Overview

Basic information about this protein and its source genome.

Accession
KP13_05481
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44486.1
Status
annotated
Amino acids
238
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
86.25

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.412
Structure A0A0H3GTR8
Pocket Pocket 4
P2Rank 0.687
Structure A0A0H3GTR8
Pocket Pocket 1
ColabFold model
FPocket 0.76 · Pocket 1
P2Rank 0.715 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 42 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
18 79 CDD cd07377 WHTH_GntR
18 79 InterPro IPR000524 Transcription regulator HTH, GntR
20 78 SMART SM00345 gntr3
20 78 InterPro IPR000524 Transcription regulator HTH, GntR
18 78 Pfam PF00392 Bacterial regulatory proteins, gntR family
18 78 InterPro IPR000524 Transcription regulator HTH, GntR
5 211 PANTHER PTHR43537 TRANSCRIPTIONAL REGULATOR, GNTR FAMILY
89 210 Pfam PF07729 FCD domain
89 210 InterPro IPR011711 GntR, C-terminal
81 219 Gene3D G3DSA:1.20.120.530 -
81 219 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
14 81 ProSiteProfiles PS50949 GntR-type HTH domain profile.
14 81 InterPro IPR000524 Transcription regulator HTH, GntR
18 82 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
18 82 InterPro IPR036390 Winged helix DNA-binding domain superfamily
84 215 SUPERFAMILY SSF48008 GntR ligand-binding domain-like
84 215 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
1 79 Gene3D G3DSA:1.10.10.10 -
1 79 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
88 211 SMART SM00895 FCD_2
88 211 InterPro IPR011711 GntR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTR8
AlphaFold — — full sequence — Viewing
ColabFold KP13_05481
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.412

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.79 0.47
2 0.76 0.002