Protein profile

KP13_05485

putative HTH-type transcriptional regulator

Genome: KpKP13

Gene: AHE44490.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GT33
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Amino acids 255
Annotations 3
Features 24
PDB binders 0
Druggability 0.429

Overview

Basic information about this protein and its source genome.

Accession
KP13_05485
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44490.1
Status
annotated
Amino acids
255
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.45

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.429
Structure A0A0H3GT33
Pocket Pocket 3
P2Rank 0.656
Structure A0A0H3GT33
Pocket Pocket 1
ColabFold model
FPocket 0.295 · Pocket 13
P2Rank 0.71 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 23 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
206 249 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature.
206 249 InterPro IPR018062 HTH domain AraC-type, conserved site
177 252 Pfam PF12833 Helix-turn-helix domain
177 252 InterPro IPR018060 DNA binding HTH domain, AraC-type
178 255 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
178 255 InterPro IPR018060 DNA binding HTH domain, AraC-type
25 115 Pfam PF02311 AraC-like ligand binding domain
25 115 InterPro IPR003313 AraC-type arabinose-binding/dimerisation domain
217 254 Gene3D G3DSA:1.10.10.60 -
171 253 SMART SM00342 aracneu4
171 253 InterPro IPR018060 DNA binding HTH domain, AraC-type
161 216 Gene3D G3DSA:1.10.10.60 -
6 252 PANTHER PTHR11019 HTH-TYPE TRANSCRIPTIONAL REGULATOR NIMR
22 185 SUPERFAMILY SSF51182 RmlC-like cupins
22 185 InterPro IPR011051 RmlC-like cupin domain superfamily
212 253 SUPERFAMILY SSF46689 Homeodomain-like
212 253 InterPro IPR009057 Homeobox-like domain superfamily
16 111 CDD cd06124 cupin_NimR-like_N
237 253 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
237 253 InterPro IPR020449 Transcription regulator HTH, AraC- type
222 237 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
222 237 InterPro IPR020449 Transcription regulator HTH, AraC- type
14 90 Gene3D G3DSA:2.60.120.10 Jelly Rolls
14 90 InterPro IPR014710 RmlC-like jelly roll fold

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GT33
AlphaFold — — full sequence — Viewing
ColabFold KP13_05485
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.429

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.32 0.443
2 5.81 0.283
3 4.49 0.191
4 2.04 0.045