Protein profile

KP13_05498

putative transmembrane protein

Genome: KpKP13

Gene: AHE44504.1 Structure source: AlphaFold + ColabFold UniProt A0A2V3K4B9
Export view
Amino acids 163
Annotations 1
Features 21
PDB binders 0
Druggability 0.556

Overview

Basic information about this protein and its source genome.

Accession
KP13_05498
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44504.1
Status
annotated
Amino acids
163
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.43

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.556
Structure A0A2V3K4B9
Pocket Pocket 3
P2Rank 0.004
Structure A0A2V3K4B9
Pocket Pocket 1
ColabFold model
FPocket 0.716 · Pocket 4
P2Rank 0.008 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 43 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
55 74 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
2 143 PANTHER PTHR34821 INNER MEMBRANE PROTEIN YDCZ
2 143 InterPro IPR006750 Putative inner membrane exporter, YdcZ
75 101 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 20 SignalP_EUK SignalP-TM SignalP-TM
121 143 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 139 Pfam PF04657 Putative inner membrane exporter, YdcZ
5 139 InterPro IPR006750 Putative inner membrane exporter, YdcZ
94 116 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
121 142 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
6 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
17 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
31 53 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
21 35 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
36 54 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
68 87 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
102 120 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
143 163 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A2V3K4B9
AlphaFold — — full sequence — Viewing
ColabFold KP13_05498
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.378
10 0.289
1 0.018
11 0.015

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 0.96 0.004