Protein profile

KP13_05501

Multidrug resistance protein A

Genome: KpKP13

Gene: emrA AHE44507.1 Structure source: AlphaFold + ColabFold UniProt W8VGM7
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Amino acids 346
Annotations 1
Features 18
PDB binders 0
Druggability 0.555

Overview

Basic information about this protein and its source genome.

Accession
KP13_05501
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
emrA AHE44507.1
Status
annotated
Amino acids
346
Structure source
AlphaFold + ColabFold
GO
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
41.72
DEG E-value
4.5400000000000003e-63
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.44

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.555
Structure W8VGM7
Pocket Pocket 12
P2Rank
Structure W8VGM7
Pocket No pockets
ColabFold model
FPocket 0.212 · Pocket 11
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 7 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
165 267 SUPERFAMILY SSF111369 HlyD-like secretion proteins
1 22 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
9 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
9 31 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
26 346 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
21 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 20 SignalP_EUK SignalP-TM SignalP-TM
1 8 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
228 345 Gene3D G3DSA:2.40.30.170 -
81 182 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
47 290 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
47 290 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
49 80 Gene3D G3DSA:2.40.50.100 -
24 335 Pfam PF00529 Cation efflux system protein CusB domain 1
24 335 InterPro IPR043602 Cation efflux system protein CusB, domain 1
48 173 SUPERFAMILY SSF111369 HlyD-like secretion proteins
11 343 PANTHER PTHR30386 MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_W8VGM7
AlphaFold — — full sequence — Viewing
ColabFold KP13_05501
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.555
2 0.002
5 0.002
1 0.0