Protein profile

KP13_05510

regulation of transcription, DNA-dependent sugar isomerase domain-containing protein

Genome: KpKP13

Gene: AHE44515.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXP4
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Amino acids 279
Annotations 6
Features 17
PDB binders 0
Druggability 0.348

Overview

Basic information about this protein and its source genome.

Accession
KP13_05510
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44515.1
Status
annotated
Amino acids
279
Structure source
AlphaFold + ColabFold
GO
GO:1901135 The chemical reactions and pathways involving carbohydrate derivative. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0097367 Binding to a carbohydrate derivative. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.45

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.348
Structure A0A0H3GXP4
Pocket Pocket 1
P2Rank 0.334
Structure A0A0H3GXP4
Pocket Pocket 1
ColabFold model
FPocket 0.442 · Pocket 4
P2Rank 0.037 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 49 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:1901135 The chemical reactions and pathways involving carbohydrate derivative.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0097367 Binding to a carbohydrate derivative.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
130 215 CDD cd04795 SIS
3 72 Pfam PF01418 Helix-turn-helix domain, rpiR family
3 72 InterPro IPR000281 Helix-turn-helix protein RpiR
1 75 Gene3D G3DSA:1.10.10.10 -
1 75 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
2 78 ProSiteProfiles PS51071 RpiR-type HTH domain profile.
2 78 InterPro IPR000281 Helix-turn-helix protein RpiR
126 245 Pfam PF01380 SIS domain
126 245 InterPro IPR001347 SIS domain
1 273 PANTHER PTHR30514 GLUCOKINASE
1 273 InterPro IPR047640 HTH-type transcriptional regulator RpiR-like
90 273 Gene3D G3DSA:3.40.50.10490 -
2 79 SUPERFAMILY SSF46689 Homeodomain-like
2 79 InterPro IPR009057 Homeobox-like domain superfamily
94 250 SUPERFAMILY SSF53697 SIS domain
94 250 InterPro IPR046348 SIS domain superfamily
266 279 Coils Coil Coil

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXP4
AlphaFold — — full sequence — Viewing
ColabFold KP13_05510
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.348

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.58 0.268
2 1.33 0.015