Protein profile

KP13_05525

hypothetical protein

Genome: KpKP13

Gene: AHE44530.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXM8
Export view
Amino acids 366
Annotations 1
Features 8
PDB binders 0
Druggability 0.598

Overview

Basic information about this protein and its source genome.

Accession
KP13_05525
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44530.1
Status
annotated
Amino acids
366
Structure source
AlphaFold + ColabFold
GO
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
92.04

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.598
Structure A0A0H3GXM8
Pocket Pocket 3
P2Rank 0.869
Structure A0A0H3GXM8
Pocket Pocket 1
ColabFold model
FPocket 0.73 · Pocket 1
P2Rank 0.895 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 8 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
123 353 PANTHER PTHR40279 PQQC-LIKE PROTEIN
123 353 InterPro IPR039068 Pyrroloquinoline-quinone synthase-like
195 300 SMART SM01236 Haem_oxygenas_2_2
165 338 Pfam PF14518 Iron-containing redox enzyme
132 346 SUPERFAMILY SSF48613 Heme oxygenase-like
132 346 InterPro IPR016084 Haem oxygenase-like, multi-helical
130 355 Gene3D G3DSA:1.20.910.10 -
130 355 InterPro IPR016084 Haem oxygenase-like, multi-helical

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXM8
AlphaFold — — full sequence — Viewing
ColabFold KP13_05525
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.035
7 0.002
5 0.0
14 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 25.89 0.869
2 8.02 0.36
3 5.85 0.237
4 3.53 0.104
5 2.74 0.067