Protein profile

KP13_05530

Major facilitator Superfamily protein

Genome: KpKP13

Gene: AHE44535.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNI8
Export view
Amino acids 432
Annotations 5
Features 50
PDB binders 4
Druggability 0.798

Overview

Basic information about this protein and its source genome.

Accession
KP13_05530
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44535.1
Status
annotated
Amino acids
432
Structure source
AlphaFold + ColabFold
GO
GO:0019531 Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0019532 The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
31.461
Human E-value
2.81e-07
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.63

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.798
Structure A0A0H3GNI8
Pocket Pocket 6
P2Rank 0.916
Structure A0A0H3GNI8
Pocket Pocket 1
ColabFold model
FPocket 0.928 · Pocket 7
P2Rank 0.94 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 18 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0019531 Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0019532 The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

50 records
Show feature table
Start End DB Term Name
98 116 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
238 257 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
70 86 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
51 69 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
117 121 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
328 332 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
332 354 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
155 177 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
258 268 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
203 237 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
29 431 NCBIfam TIGR04259 oxalate/formate MFS antiporter
29 431 InterPro IPR026355 Oxalate/formate antiporter
122 146 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
290 309 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
28 402 PANTHER PTHR11360 MONOCARBOXYLATE TRANSPORTER
87 97 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
237 432 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
237 432 InterPro IPR020846 Major facilitator superfamily domain
178 182 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
49 281 Pfam PF07690 Major Facilitator Superfamily
49 281 InterPro IPR011701 Major facilitator superfamily
183 202 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
267 286 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 32 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
187 206 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
68 85 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
373 392 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
398 420 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
421 432 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
147 154 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
29 428 SUPERFAMILY SSF103473 MFS general substrate transporter
29 428 InterPro IPR036259 MFS transporter superfamily
310 327 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
120 142 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
238 257 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
369 391 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
29 419 CDD cd17353 MFS_OFA_like
25 208 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
25 208 InterPro IPR036259 MFS transporter superfamily
230 426 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
230 426 InterPro IPR036259 MFS transporter superfamily
155 177 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
33 50 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
333 353 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
98 116 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
393 397 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
398 420 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
354 372 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
33 53 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
269 289 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNI8
AlphaFold — — full sequence — Viewing
ColabFold KP13_05530
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.798

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 24.3 0.897
2 2.83 0.088
3 2.54 0.071
4 1.75 0.032
5 1.66 0.028

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

54 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
02Q
6ZGU
A0LNN5 164.2 Da LogP 2.01 TPSA 37.3 ✓ Ro5 ✓ Clean Cc1ccccc1CCC(=O)O
1HN
6ZGR
A0LNN5 188.2 Da LogP 2.24 TPSA 57.5 ✓ Ro5 ✓ Clean c1ccc2c(c1)ccc(c2O)C(=O)O
FIV
6ZGT
A0LNN5 172.2 Da LogP 2.54 TPSA 37.3 ✓ Ro5 ✓ Clean c1ccc2cc(ccc2c1)C(=O)O
HCI
6ZGS
A0LNN5 150.2 Da LogP 1.70 TPSA 37.3 ✓ Ro5 ✓ Clean c1ccc(cc1)CCC(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.