Protein profile

KP13_05532

putative PTS system mannitol-specific EIIA component

Genome: KpKP13

Gene: AHE44538.1 cmtB Structure source: AlphaFold + ColabFold UniProt A0A0H3GT02
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Amino acids 145
Annotations 3
Features 12
PDB binders 0
Druggability 0.77

Overview

Basic information about this protein and its source genome.

Accession
KP13_05532
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44538.1 cmtB
Status
annotated
Amino acids
145
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
41.228
DEG E-value
2.6799999999999998e-25
Localization
CytoplasmicMembrane
ColabFold pLDDT
95.18

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.77
Structure A0A0H3GT02
Pocket Pocket 2
P2Rank 0.017
Structure A0A0H3GT02
Pocket Pocket 1
ColabFold model
FPocket 0.471 · Pocket 2
P2Rank 0.062 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 13 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
  • GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
6 144 CDD cd00211 PTS_IIA_fru
6 144 InterPro IPR002178 PTS EIIA type-2 domain
4 145 ProSiteProfiles PS51094 PTS_EIIA type-2 domain profile.
4 145 InterPro IPR002178 PTS EIIA type-2 domain
51 67 ProSitePatterns PS00372 PTS EIIA domains phosphorylation site signature 2.
51 67 InterPro IPR002178 PTS EIIA type-2 domain
4 144 PANTHER PTHR36203 ASCORBATE-SPECIFIC PTS SYSTEM EIIA COMPONENT
1 145 Gene3D G3DSA:3.40.930.10 -
1 145 InterPro IPR016152 Phosphotransferase/anion transporter
6 144 Pfam PF00359 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
1 144 SUPERFAMILY SSF55804 Phoshotransferase/anion transport protein
1 144 InterPro IPR016152 Phosphotransferase/anion transporter

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GT02
AlphaFold — — full sequence — Viewing
ColabFold KP13_05532
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.77