Protein profile

KP13_05544

Cell envelope integrity inner membrane protein

Genome: KpKP13

Gene: AHE44550.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNH5
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Amino acids 142
Annotations 3
Features 13
PDB binders 0
Druggability 0.006

Overview

Basic information about this protein and its source genome.

Accession
KP13_05544
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44550.1
Status
annotated
Amino acids
142
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0019534 Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. GO:0043213 The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
86.02

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.006
Structure A0A0H3GNH5
Pocket Pocket 1
P2Rank
Structure A0A0H3GNH5
Pocket No pockets
ColabFold model
FPocket 0.755 · Pocket 3
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 7 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0019534 Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.
  • GO:0043213 The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
55 142 Gene3D G3DSA:3.30.1150.10 -
58 142 SUPERFAMILY SSF74653 TolA/TonB C-terminal domain
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 20 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 26 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 30 Phobius SIGNAL_PEPTIDE Signal peptide region
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
19 30 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
54 140 Pfam PF06519 TolA C-terminal
54 140 InterPro IPR014161 Tol-Pal system, TolA
31 142 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 26 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNH5
AlphaFold — — full sequence — Viewing
ColabFold KP13_05544
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer