Protein profile

KP13_05560

Phosphoglycerate transport regulatory protein pgtC

Genome: KpKP13

Gene: AHE44566.1 pgtC Structure source: AlphaFold + ColabFold UniProt A0A0H3GSX6
Export view
Amino acids 374
Annotations 1
Features 6
PDB binders 0
Druggability 0.765

Overview

Basic information about this protein and its source genome.

Accession
KP13_05560
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44566.1 pgtC
Status
annotated
Amino acids
374
Structure source
AlphaFold + ColabFold
GO
GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
94.24

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.765
Structure A0A0H3GSX6
Pocket Pocket 1
P2Rank 0.131
Structure A0A0H3GSX6
Pocket Pocket 1
ColabFold model
FPocket 0.172 · Pocket 27
P2Rank 0.726 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 26 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
16 36 Coils Coil Coil
89 260 Gene3D G3DSA:3.40.190.10 -
36 280 Pfam PF13343 Bacterial extracellular solute-binding protein
4 288 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
20 259 Gene3D G3DSA:3.40.190.10 -
2 314 PANTHER PTHR30006 THIAMINE-BINDING PERIPLASMIC PROTEIN-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSX6
AlphaFold — — full sequence — Viewing
ColabFold KP13_05560
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.765

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.65 0.027
2 1.18 0.01