Protein profile

KP13_05184

putative hydrolase

Genome: KpKP13

Gene: AHE44588.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSW5
Export view
Amino acids 365
Annotations 1
Features 16
PDB binders 0
Druggability 0.495

Overview

Basic information about this protein and its source genome.

Accession
KP13_05184
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44588.1
Status
annotated
Amino acids
365
Structure source
AlphaFold + ColabFold
GO
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
89.79

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.495
Structure A0A0H3GSW5
Pocket Pocket 1
P2Rank 0.944
Structure A0A0H3GSW5
Pocket Pocket 1
ColabFold model
FPocket 0.832 · Pocket 19
P2Rank 0.943 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 872 / 4744 genomes with a hit
Normalized 0.184

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 35 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
36 365 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 35 Phobius SIGNAL_PEPTIDE Signal peptide region
202 292 Gene3D G3DSA:1.10.10.800 -
202 292 FunFam G3DSA:1.10.10.800:FF:000002 OpdE downstream ORF 2, putative
45 364 SUPERFAMILY SSF53474 alpha/beta-Hydrolases
45 364 InterPro IPR029058 Alpha/Beta hydrolase fold
19 30 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 35 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 18 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
65 359 Gene3D G3DSA:3.40.50.1820 alpha/beta hydrolase
65 359 InterPro IPR029058 Alpha/Beta hydrolase fold
74 239 Pfam PF02129 X-Pro dipeptidyl-peptidase (S15 family)
74 239 InterPro IPR000383 Xaa-Pro dipeptidyl-peptidase-like domain
31 35 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
50 363 PANTHER PTHR47751 SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSW5
AlphaFold — — full sequence — Viewing
ColabFold KP13_05184
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.495

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 28.92 0.928
2 0.88 0.004
3 0.77 0.002