Protein profile

KP13_05194

Glyoxalase/bleomycin resistance protein/dioxygenase family protein

Genome: KpKP13

Gene: AHE44598.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTH0
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Amino acids 129
Annotations 2
Features 12
PDB binders 0
Druggability 0.601

Overview

Basic information about this protein and its source genome.

Accession
KP13_05194
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44598.1
Status
annotated
Amino acids
129
Structure source
AlphaFold + ColabFold
GO
GO:0004462 Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.65

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.601
Structure A0A0H3GTH0
Pocket Pocket 2
P2Rank 0.014
Structure A0A0H3GTH0
Pocket Pocket 1
ColabFold model
FPocket 0.302 · Pocket 8
P2Rank 0.016 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 5 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0004462 Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
5 123 PANTHER PTHR43048 METHYLMALONYL-COA EPIMERASE
10 30 ProSitePatterns PS00934 Glyoxalase I signature 1.
10 30 InterPro IPR018146 Glyoxalase I, conserved site
2 125 Gene3D G3DSA:3.10.180.10 -
2 125 InterPro IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
10 124 CDD cd06587 VOC
8 124 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
8 124 InterPro IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
5 126 SUPERFAMILY SSF54593 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
5 126 InterPro IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
7 127 ProSiteProfiles PS51819 Vicinal oxygen chelate (VOC) domain profile.
7 127 InterPro IPR037523 Vicinal oxygen chelate (VOC) domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTH0
AlphaFold — — full sequence — Viewing
ColabFold KP13_05194
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.601
1 0.017
3 0.0
6 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.39 0.014
2 1.09 0.007