Protein profile

KP13_05221

Putative outer membrane usher protein

Genome: KpKP13

Gene: AHE44628.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXE2
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Amino acids 833
Annotations 5
Features 26
PDB binders 0
Druggability 0.302

Overview

Basic information about this protein and its source genome.

Accession
KP13_05221
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44628.1
Status
annotated
Amino acids
833
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
85.54

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.302
Structure A0A0H3GXE2
Pocket Pocket 70
P2Rank 0.47
Structure A0A0H3GXE2
Pocket Pocket 1
ColabFold model
FPocket 0.444 · Pocket 45
P2Rank 0.423 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 4 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005515 Binding to a protein.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone.
  • GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
1 27 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
29 153 Gene3D G3DSA:3.10.20.410 -
29 153 InterPro IPR037224 PapC, N-terminal domain superfamily
56 167 SUPERFAMILY SSF141729 FimD N-terminal domain-like
56 167 InterPro IPR037224 PapC, N-terminal domain superfamily
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
9 831 PANTHER PTHR30451 OUTER MEMBRANE USHER PROTEIN
9 831 InterPro IPR000015 Outer membrane usher protein
749 832 Gene3D G3DSA:2.60.40.2070 -
749 832 InterPro IPR043142 PapC-like, C-terminal domain superfamily
658 748 Gene3D G3DSA:2.60.40.2610 Outer membrane usher protein FimD, plug domain
658 748 InterPro IPR042186 Outer membrane usher protein FimD, plug domain
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
30 175 Pfam PF13954 PapC N-terminal domain
30 175 InterPro IPR025885 PapC, N-terminal domain
261 350 FunFam G3DSA:2.60.40.3110:FF:000001 Putative fimbrial outer membrane usher
1 29 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
261 350 Gene3D G3DSA:2.60.40.3110 -
28 833 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
20 27 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
191 743 Pfam PF00577 Outer membrane usher protein
191 743 InterPro IPR000015 Outer membrane usher protein
8 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 27 Phobius SIGNAL_PEPTIDE Signal peptide region
752 813 Pfam PF13953 PapC C-terminal domain
752 813 InterPro IPR025949 PapC-like, C-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXE2
AlphaFold — — full sequence — Viewing
ColabFold KP13_05221
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
70 0.302
3 0.283

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.51 0.263
2 5.16 0.238