Protein profile

KP13_05225

putative DNA-binding transcriptional regulator HipB

Genome: KpKP13

Gene: AHE44632.1 Structure source: AlphaFold + ColabFold UniProt A0A377TVX2
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Amino acids 79
Annotations 1
Features 11
PDB binders 0

Overview

Basic information about this protein and its source genome.

Accession
KP13_05225
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44632.1
Status
annotated
Amino acids
79
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
61.538
DEG E-value
2.08e-28
Localization
Unknown
ColabFold pLDDT
88.62

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket
Structure A0A377TVX2
Pocket No pockets
P2Rank
Structure A0A377TVX2
Pocket No pockets
ColabFold model
FPocket 0.271 · Pocket 3
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 14 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 60 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
1 60 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
6 61 SMART SM00530 mbf_short4
6 61 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
7 56 Pfam PF01381 Helix-turn-helix
7 56 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
1 79 Gene3D G3DSA:1.10.260.40 -
1 79 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
7 60 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
7 60 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
7 56 CDD cd00093 HTH_XRE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A377TVX2
AlphaFold — — full sequence — Viewing
ColabFold KP13_05225
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer